Trends in Managing Cardiac and Orthopaedic Device-Associated Infections by Using Therapeutic Biomaterials

• Main Authors: Stefania Scialla, Giorgia Martuscelli, Francesco Nappi, Sanjeet Singh Avtaar Singh, Adelaide Iervolino, Domenico Larobina, Luigi Ambrosio, Maria Grazia Raucci
• Format: Article
• Language: English
• Published: MDPI AG 2021-05-01
• Series: Polymers
• Subjects: cardiac-associated infections; orthopaedic-associated infections; biofilm; passive antifouling strategies; active antimicrobial strategies; antimicrobial peptides
• Online Access: https://www.mdpi.com/2073-4360/13/10/1556

Over the years, there has been an increasing number of cardiac and orthopaedic implanted medical devices, which has caused an increased incidence of device-associated infections. The surfaces of these indwelling devices are preferred sites for the development of biofilms that are potentially lethal for patients. Device-related infections form a large proportion of hospital-acquired infections and have a bearing on both morbidity and mortality. Treatment of these infections is limited to the use of systemic antibiotics with invasive revision surgeries, which had implications on healthcare burdens. The purpose of this review is to describe the main causes that lead to the onset of infection, highlighting both the biological and clinical pathophysiology. Both passive and active surface treatments have been used in the field of biomaterials to reduce the impact of these infections. This includes the use of antimicrobial peptides and ionic liquids in the preventive treatment of antibiotic-resistant biofilms. Thus far, multiple in vivo studies have shown efficacious effects against the antibiotic-resistant biofilm. However, this has yet to materialize in clinical medicine.