Autoantibodies in Autoimmune Pancreatitis
Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper-γ-globulinaemia, and antinuclear antibody (ANA) positivity serologically. The main differential diagnosis, is pancreatic cancer, which can be ruled...
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doaj-849420ab5d354e3c854966c74cc167302020-11-24T22:31:15ZengHindawi LimitedInternational Journal of Rheumatology1687-92601687-92792012-01-01201210.1155/2012/940831940831Autoantibodies in Autoimmune PancreatitisDaniel S. Smyk0Eirini I. Rigopoulou1Andreas L. Koutsoumpas2Stephen Kriese3Andrew K. Burroughs4Dimitrios P. Bogdanos5Institute of Liver Studies, King's College London School of Medicine, King’s College Hospital, Denmark Hill, London SE5 9RS, UKDepartment of Medicine, University of Thessaly Medical School, Viopolis, 41110 Larissa, GreeceInstitute of Liver Studies, King's College London School of Medicine, King’s College Hospital, Denmark Hill, London SE5 9RS, UKInstitute of Liver Studies, King's College London School of Medicine, King’s College Hospital, Denmark Hill, London SE5 9RS, UKThe Sheila Sherlock Liver Centre and University Department of Surgery, Royal Free Hospital, London NW3 2QG, UKInstitute of Liver Studies, King's College London School of Medicine, King’s College Hospital, Denmark Hill, London SE5 9RS, UKAutoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper-γ-globulinaemia, and antinuclear antibody (ANA) positivity serologically. The main differential diagnosis, is pancreatic cancer, which can be ruled out through radiological, serological, and histological investigations. The targets of ANA in patients with autoimmune pancreatitis do not appear to be similar to those found in other rheumatological diseases, as dsDNA, SS-A, and SS-B are not frequently recognized by AIP-related ANA. Other disease-specific autoantibodies, such as, antimitochondrial, antineutrophil cytoplasmic antibodies or diabetes-specific autoantibodies are virtually absent. Further studies have focused on the identification of pancreas-specific autoantigens and reported significant reactivity to lactoferrin, carbonic anhydrase, pancreas secretory trypsin inhibitor, amylase-alpha, heat-shock protein, and plasminogen-binding protein. This paper discusses the findings of these investigations and their relevance to the diagnosis, management, and pathogenesis of autoimmune pancreatitis.http://dx.doi.org/10.1155/2012/940831 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel S. Smyk Eirini I. Rigopoulou Andreas L. Koutsoumpas Stephen Kriese Andrew K. Burroughs Dimitrios P. Bogdanos |
spellingShingle |
Daniel S. Smyk Eirini I. Rigopoulou Andreas L. Koutsoumpas Stephen Kriese Andrew K. Burroughs Dimitrios P. Bogdanos Autoantibodies in Autoimmune Pancreatitis International Journal of Rheumatology |
author_facet |
Daniel S. Smyk Eirini I. Rigopoulou Andreas L. Koutsoumpas Stephen Kriese Andrew K. Burroughs Dimitrios P. Bogdanos |
author_sort |
Daniel S. Smyk |
title |
Autoantibodies in Autoimmune Pancreatitis |
title_short |
Autoantibodies in Autoimmune Pancreatitis |
title_full |
Autoantibodies in Autoimmune Pancreatitis |
title_fullStr |
Autoantibodies in Autoimmune Pancreatitis |
title_full_unstemmed |
Autoantibodies in Autoimmune Pancreatitis |
title_sort |
autoantibodies in autoimmune pancreatitis |
publisher |
Hindawi Limited |
series |
International Journal of Rheumatology |
issn |
1687-9260 1687-9279 |
publishDate |
2012-01-01 |
description |
Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper-γ-globulinaemia, and antinuclear antibody (ANA) positivity serologically. The main differential diagnosis, is pancreatic cancer, which can be ruled out through radiological, serological, and histological investigations. The targets of ANA in patients with autoimmune pancreatitis do not appear to be similar to those found in other rheumatological diseases, as dsDNA, SS-A, and SS-B are not frequently recognized by AIP-related ANA. Other disease-specific autoantibodies, such as, antimitochondrial, antineutrophil cytoplasmic antibodies or diabetes-specific autoantibodies are virtually absent. Further studies have focused on the identification of pancreas-specific autoantigens and reported significant reactivity to lactoferrin, carbonic anhydrase, pancreas secretory trypsin inhibitor, amylase-alpha, heat-shock protein, and plasminogen-binding protein. This paper discusses the findings of these investigations and their relevance to the diagnosis, management, and pathogenesis of autoimmune pancreatitis. |
url |
http://dx.doi.org/10.1155/2012/940831 |
work_keys_str_mv |
AT danielssmyk autoantibodiesinautoimmunepancreatitis AT eiriniirigopoulou autoantibodiesinautoimmunepancreatitis AT andreaslkoutsoumpas autoantibodiesinautoimmunepancreatitis AT stephenkriese autoantibodiesinautoimmunepancreatitis AT andrewkburroughs autoantibodiesinautoimmunepancreatitis AT dimitriospbogdanos autoantibodiesinautoimmunepancreatitis |
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