Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer
Esophageal cancer (EC) is an aggressive form of cancer, including squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) as two predominant histological subtypes. Accumulating evidence supports the existence of cancer stem cells (CSCs) able to initiate and maintain EAC or ESCC. In this review, we a...
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doaj-8497a1ce603849c2b66c94e1a1f9b4c72020-11-25T03:07:16ZengMDPI AGCells2073-44092020-06-0191481148110.3390/cells9061481Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal CancerChenghui Zhou0Ningbo Fan1Fanyu Liu2Nan Fang3Patrick S. Plum4René Thieme5Ines Gockel6Sascha Gromnitza7Axel M. Hillmer8Seung-Hun Chon9Hans A. Schlösser10Christiane J. Bruns11Yue Zhao12Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 50937 Cologne, GermanySingleron Biotechnologies, Yaogu Avenue 11, Nanjing 210000, ChinaDepartment of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, 4107 Leipzig, GermanyDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, 4107 Leipzig, GermanyInstitute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyInstitute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 50937 Cologne, GermanyDepartment of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 50937 Cologne, GermanyEsophageal cancer (EC) is an aggressive form of cancer, including squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) as two predominant histological subtypes. Accumulating evidence supports the existence of cancer stem cells (CSCs) able to initiate and maintain EAC or ESCC. In this review, we aim to collect the current evidence on CSCs in esophageal cancer, including the biomarkers/characterization strategies of CSCs, heterogeneity of CSCs, and the key signaling pathways (Wnt/β-catenin, Notch, Hedgehog, YAP, JAK/STAT3) in modulating CSCs during esophageal cancer progression. Exploring the molecular mechanisms of therapy resistance in EC highlights DNA damage response (DDR), metabolic reprogramming, epithelial mesenchymal transition (EMT), and the role of the crosstalk of CSCs and their niche in the tumor progression. According to these molecular findings, potential therapeutic implications of targeting esophageal CSCs may provide novel strategies for the clinical management of esophageal cancer.https://www.mdpi.com/2073-4409/9/6/1481esophageal cancerheterogeneitycancer stem cellplasticitytherapeutic resistance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chenghui Zhou Ningbo Fan Fanyu Liu Nan Fang Patrick S. Plum René Thieme Ines Gockel Sascha Gromnitza Axel M. Hillmer Seung-Hun Chon Hans A. Schlösser Christiane J. Bruns Yue Zhao |
spellingShingle |
Chenghui Zhou Ningbo Fan Fanyu Liu Nan Fang Patrick S. Plum René Thieme Ines Gockel Sascha Gromnitza Axel M. Hillmer Seung-Hun Chon Hans A. Schlösser Christiane J. Bruns Yue Zhao Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer Cells esophageal cancer heterogeneity cancer stem cell plasticity therapeutic resistance |
author_facet |
Chenghui Zhou Ningbo Fan Fanyu Liu Nan Fang Patrick S. Plum René Thieme Ines Gockel Sascha Gromnitza Axel M. Hillmer Seung-Hun Chon Hans A. Schlösser Christiane J. Bruns Yue Zhao |
author_sort |
Chenghui Zhou |
title |
Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer |
title_short |
Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer |
title_full |
Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer |
title_fullStr |
Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer |
title_full_unstemmed |
Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer |
title_sort |
linking cancer stem cell plasticity to therapeutic resistance-mechanism and novel therapeutic strategies in esophageal cancer |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-06-01 |
description |
Esophageal cancer (EC) is an aggressive form of cancer, including squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) as two predominant histological subtypes. Accumulating evidence supports the existence of cancer stem cells (CSCs) able to initiate and maintain EAC or ESCC. In this review, we aim to collect the current evidence on CSCs in esophageal cancer, including the biomarkers/characterization strategies of CSCs, heterogeneity of CSCs, and the key signaling pathways (Wnt/β-catenin, Notch, Hedgehog, YAP, JAK/STAT3) in modulating CSCs during esophageal cancer progression. Exploring the molecular mechanisms of therapy resistance in EC highlights DNA damage response (DDR), metabolic reprogramming, epithelial mesenchymal transition (EMT), and the role of the crosstalk of CSCs and their niche in the tumor progression. According to these molecular findings, potential therapeutic implications of targeting esophageal CSCs may provide novel strategies for the clinical management of esophageal cancer. |
topic |
esophageal cancer heterogeneity cancer stem cell plasticity therapeutic resistance |
url |
https://www.mdpi.com/2073-4409/9/6/1481 |
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