Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli
Aberrations in the elaboration of both aversive and rewarding stimuli characterize several psychopathologies including anxiety, depression and addiction. Several studies suggest that different neurotrasmitters, within the corticolimbic system, are critically involved in the processing of positive an...
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00207/full |
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doaj-849d15874a734161a678f5ac0c96ec232020-11-24T21:03:51ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372015-02-01810.3389/fnsys.2014.00207105652Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuliDiego eAndolina0Diego eAndolina1Stefano ePuglisi-Allegra2Stefano ePuglisi-Allegra3Rossella eVentura4Rossella eVentura5Universita` degli Studi dell’AquilaSanta Lucia FoundationUniversità di Roma SapienzaSanta Lucia FoundationUniversità di Roma SapienzaSanta Lucia FoundationAberrations in the elaboration of both aversive and rewarding stimuli characterize several psychopathologies including anxiety, depression and addiction. Several studies suggest that different neurotrasmitters, within the corticolimbic system, are critically involved in the processing of positive and negative stimuli. Individual differences in this system, depending on genotype, have been shown to act as a liability factor for different psychopathologies. Inbred mouse strains are commonly used in preclinical studies of normal and pathological behaviors. In particular, C57BL/6J (C57) and DBA/2J (DBA) strains have permitted to disclose the impact of different genetic backgrounds over the corticolimbic system functions. Here, we summarize the main findings collected over the years in our laboratory, showing how the genetic background plays a critical role in modulating amminergic and GABAergic neurotransmission in prefrontal-accumbal-amygdala system response to different rewarding and aversive experiences, as well as to stress response. Finally, we propose a top-down model for the response to rewarding and aversive stimuli in which amminergic transmission in PFC controls accumbal and amygdala neurotransmitter response.http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00207/fullstressneurotransmissionStraincorticolimbicrewarding stimuli |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Diego eAndolina Diego eAndolina Stefano ePuglisi-Allegra Stefano ePuglisi-Allegra Rossella eVentura Rossella eVentura |
spellingShingle |
Diego eAndolina Diego eAndolina Stefano ePuglisi-Allegra Stefano ePuglisi-Allegra Rossella eVentura Rossella eVentura Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli Frontiers in Systems Neuroscience stress neurotransmission Strain corticolimbic rewarding stimuli |
author_facet |
Diego eAndolina Diego eAndolina Stefano ePuglisi-Allegra Stefano ePuglisi-Allegra Rossella eVentura Rossella eVentura |
author_sort |
Diego eAndolina |
title |
Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli |
title_short |
Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli |
title_full |
Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli |
title_fullStr |
Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli |
title_full_unstemmed |
Strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli |
title_sort |
strain-dependent differences in corticolimbic processing of aversive or rewarding stimuli |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Systems Neuroscience |
issn |
1662-5137 |
publishDate |
2015-02-01 |
description |
Aberrations in the elaboration of both aversive and rewarding stimuli characterize several psychopathologies including anxiety, depression and addiction. Several studies suggest that different neurotrasmitters, within the corticolimbic system, are critically involved in the processing of positive and negative stimuli. Individual differences in this system, depending on genotype, have been shown to act as a liability factor for different psychopathologies. Inbred mouse strains are commonly used in preclinical studies of normal and pathological behaviors. In particular, C57BL/6J (C57) and DBA/2J (DBA) strains have permitted to disclose the impact of different genetic backgrounds over the corticolimbic system functions. Here, we summarize the main findings collected over the years in our laboratory, showing how the genetic background plays a critical role in modulating amminergic and GABAergic neurotransmission in prefrontal-accumbal-amygdala system response to different rewarding and aversive experiences, as well as to stress response. Finally, we propose a top-down model for the response to rewarding and aversive stimuli in which amminergic transmission in PFC controls accumbal and amygdala neurotransmitter response. |
topic |
stress neurotransmission Strain corticolimbic rewarding stimuli |
url |
http://journal.frontiersin.org/Journal/10.3389/fnsys.2014.00207/full |
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