Quantification of Lutein + Zeaxanthin Presence in Human Placenta and Correlations with Blood Levels and Maternal Dietary Intake
Lutein + zeaxanthin (L + Z) are carotenoids recognized in eye health, but less is known about their status during pregnancy. While quantified in maternal and umbilical cord blood, they have never been analyzed in placenta. The purpose of this study is to quantify combined L + Z concentrations in hum...
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doaj-84af6e3f62ba4dba895fa28bd92887382020-11-25T00:04:38ZengMDPI AGNutrients2072-66432019-01-0111113410.3390/nu11010134nu11010134Quantification of Lutein + Zeaxanthin Presence in Human Placenta and Correlations with Blood Levels and Maternal Dietary IntakeMelissa Thoene0Ann Anderson-Berry1Matthew Van Ormer2Jeremy Furtado3Ghada A. Soliman4Whitney Goldner5Corrine Hanson6Department of Pharmacy and Nutrition, Nebraska Medicine, 981200 Nebraska Medical Center, Omaha, NE 68198, USADepartment of Pediatrics, University of Nebraska Medical Center, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USADepartment of Pediatrics, University of Nebraska Medical Center, 981205 Nebraska Medical Center, Omaha, NE 68198-1205, USADepartment of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02215, USAGraduate School of Public Health and Health Policy, City University of New York, 55 West 125th Street, New York, NY 10027, USADivision of Endocrinology, University of Nebraska Medical Center, Omaha, 984130 Nebraska Medical Center, Omaha NE 68198-4130, USACollege of Allied Health Professions, University of Nebraska Medical Center, 984045 Nebraska Medical Center, Omaha, NE 68198-4045, USALutein + zeaxanthin (L + Z) are carotenoids recognized in eye health, but less is known about their status during pregnancy. While quantified in maternal and umbilical cord blood, they have never been analyzed in placenta. The purpose of this study is to quantify combined L + Z concentrations in human placenta and correlate with levels in maternal dietary intake, maternal serum, and umbilical cord blood. The proportions of combined L + Z were compared within diet, placenta, maternal serum, and umbilical cord blood among additional carotenoids (lycopene, β-cryptoxanthin, α-carotene, and β-carotene). This Institutional Review Boardapproved cross-sectional study enrolled 82 mother-infant pairs. Placenta, maternal serum, and umbilical cord blood samples were analyzed for carotenoids concentrations. Mothers completed a food frequency questionnaire and demographic/birth outcome data were collected. L + Z were present in placenta, median 0.105 micrograms/gram (mcg/g) and were significantly correlated with maternal serum (r = 0.57; p < 0.001), umbilical cord blood levels (r = 0.49; p = 0.001), but not dietary intake (p = 0.110). L + Z were the most prevalent in placenta (49.1%) umbilical cord blood (37.0%), but not maternal serum (18.6%) or dietary intake (19.4%). Rate of transfer was 16.0%, the highest of all carotenoids. Conclusively, L + Z were identified as the two most prevalent in placenta. Results highlight unique roles L + Z may play during pregnancy.http://www.mdpi.com/2072-6643/11/1/134luteinzeaxanthincarotenoidplacentapregnancy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Melissa Thoene Ann Anderson-Berry Matthew Van Ormer Jeremy Furtado Ghada A. Soliman Whitney Goldner Corrine Hanson |
spellingShingle |
Melissa Thoene Ann Anderson-Berry Matthew Van Ormer Jeremy Furtado Ghada A. Soliman Whitney Goldner Corrine Hanson Quantification of Lutein + Zeaxanthin Presence in Human Placenta and Correlations with Blood Levels and Maternal Dietary Intake Nutrients lutein zeaxanthin carotenoid placenta pregnancy |
author_facet |
Melissa Thoene Ann Anderson-Berry Matthew Van Ormer Jeremy Furtado Ghada A. Soliman Whitney Goldner Corrine Hanson |
author_sort |
Melissa Thoene |
title |
Quantification of Lutein + Zeaxanthin Presence in Human Placenta and Correlations with Blood Levels and Maternal Dietary Intake |
title_short |
Quantification of Lutein + Zeaxanthin Presence in Human Placenta and Correlations with Blood Levels and Maternal Dietary Intake |
title_full |
Quantification of Lutein + Zeaxanthin Presence in Human Placenta and Correlations with Blood Levels and Maternal Dietary Intake |
title_fullStr |
Quantification of Lutein + Zeaxanthin Presence in Human Placenta and Correlations with Blood Levels and Maternal Dietary Intake |
title_full_unstemmed |
Quantification of Lutein + Zeaxanthin Presence in Human Placenta and Correlations with Blood Levels and Maternal Dietary Intake |
title_sort |
quantification of lutein + zeaxanthin presence in human placenta and correlations with blood levels and maternal dietary intake |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-01-01 |
description |
Lutein + zeaxanthin (L + Z) are carotenoids recognized in eye health, but less is known about their status during pregnancy. While quantified in maternal and umbilical cord blood, they have never been analyzed in placenta. The purpose of this study is to quantify combined L + Z concentrations in human placenta and correlate with levels in maternal dietary intake, maternal serum, and umbilical cord blood. The proportions of combined L + Z were compared within diet, placenta, maternal serum, and umbilical cord blood among additional carotenoids (lycopene, β-cryptoxanthin, α-carotene, and β-carotene). This Institutional Review Boardapproved cross-sectional study enrolled 82 mother-infant pairs. Placenta, maternal serum, and umbilical cord blood samples were analyzed for carotenoids concentrations. Mothers completed a food frequency questionnaire and demographic/birth outcome data were collected. L + Z were present in placenta, median 0.105 micrograms/gram (mcg/g) and were significantly correlated with maternal serum (r = 0.57; p < 0.001), umbilical cord blood levels (r = 0.49; p = 0.001), but not dietary intake (p = 0.110). L + Z were the most prevalent in placenta (49.1%) umbilical cord blood (37.0%), but not maternal serum (18.6%) or dietary intake (19.4%). Rate of transfer was 16.0%, the highest of all carotenoids. Conclusively, L + Z were identified as the two most prevalent in placenta. Results highlight unique roles L + Z may play during pregnancy. |
topic |
lutein zeaxanthin carotenoid placenta pregnancy |
url |
http://www.mdpi.com/2072-6643/11/1/134 |
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