Subacute Assessment of the Toxicity and Antidepressant-Like Effects of <i>Origanum Majorana</i> L. Polyphenols in Swiss Albino Mice
<i>Origanum majorana </i>L. is a plant commonly used in folk medicine to treat depression and several neurological disorders. This study aims to evaluate the antidepressant-like effect of the <i>Origanum majorana</i> L. polyphenols (OMP) obtained from the aerial parts using t...
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doaj-84b1439eb9a24be0958894770b4e47612020-12-01T00:03:31ZengMDPI AGMolecules1420-30492020-11-01255653565310.3390/molecules25235653Subacute Assessment of the Toxicity and Antidepressant-Like Effects of <i>Origanum Majorana</i> L. Polyphenols in Swiss Albino MiceAmal Amaghnouje0Hamza Mechchate1Imane Es-safi2Smahane Boukhira3Ali S. Aliqahtani4Omar M. Noman5Fahd A. Nasr6Raffaele Conte7Anna Calarco8Dalila Bousta9Laboratory of Biotechnology, Environment, Agrifood, and Health (LBEAS), Faculty of Sciences, University Sidi Mohammed Ben Abdellah, BP 1796-ATLAS, FES, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health (LBEAS), Faculty of Sciences, University Sidi Mohammed Ben Abdellah, BP 1796-ATLAS, FES, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health (LBEAS), Faculty of Sciences, University Sidi Mohammed Ben Abdellah, BP 1796-ATLAS, FES, MoroccoLaboratory of Biotechnology, Environment, Agrifood, and Health (LBEAS), Faculty of Sciences, University Sidi Mohammed Ben Abdellah, BP 1796-ATLAS, FES, MoroccoDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaResearch Institute on Terrestrial Ecosystems (IRET)—CNR, Via Pietro Castellino 111, 80131 Naples, ItalyResearch Institute on Terrestrial Ecosystems (IRET)—CNR, Via Pietro Castellino 111, 80131 Naples, ItalyLaboratory of Biotechnology, Environment, Agrifood, and Health (LBEAS), Faculty of Sciences, University Sidi Mohammed Ben Abdellah, BP 1796-ATLAS, FES, Morocco<i>Origanum majorana </i>L. is a plant commonly used in folk medicine to treat depression and several neurological disorders. This study aims to evaluate the antidepressant-like effect of the <i>Origanum majorana</i> L. polyphenols (OMP) obtained from the aerial parts using two different depression model tests: the forced swimming test (FST) and the tail suspension test (TST) in Swiss albino mice. The experiments were performed on days 1, 7, 14, and 21 with daily administration of different treatments. Two different doses were chosen for this study (50 and 100 mg/kg), and paroxetine was used as a positive control. Immobility as a consequence of the depression state was significantly reduced following the treatment with OMP, indicating an antidepressant effect. A subacute toxicity study was also performed following the Organization for Economic Co-operation and Development (OECD) Guidelines (407), showing no sign of toxicity for the studied doses. The phytochemical screening revealed the presence of 12 components, all belonging to polyphenols: arbutin, rosmarinic acid, ursolic acid, quercetin-3-<i>O</i>-glucoside, quercetin-7-<i>O</i>-glucuronic acid, luteolin-7-<i>O</i>-glucoside, kaempferol-3-0-glucuronic acid, Kaempferol-3-0-pentose, caffeic acid, catechin, quercetin, and rutin. These findings suggest that <i>O. majorana</i> has interesting antidepressant-like properties, which deserve further investigation.https://www.mdpi.com/1420-3049/25/23/5653<i>Origanum majorana</i> L.polyphenolsantidepressant-likeforced swimming testtail suspension testOECD 407 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amal Amaghnouje Hamza Mechchate Imane Es-safi Smahane Boukhira Ali S. Aliqahtani Omar M. Noman Fahd A. Nasr Raffaele Conte Anna Calarco Dalila Bousta |
spellingShingle |
Amal Amaghnouje Hamza Mechchate Imane Es-safi Smahane Boukhira Ali S. Aliqahtani Omar M. Noman Fahd A. Nasr Raffaele Conte Anna Calarco Dalila Bousta Subacute Assessment of the Toxicity and Antidepressant-Like Effects of <i>Origanum Majorana</i> L. Polyphenols in Swiss Albino Mice Molecules <i>Origanum majorana</i> L. polyphenols antidepressant-like forced swimming test tail suspension test OECD 407 |
author_facet |
Amal Amaghnouje Hamza Mechchate Imane Es-safi Smahane Boukhira Ali S. Aliqahtani Omar M. Noman Fahd A. Nasr Raffaele Conte Anna Calarco Dalila Bousta |
author_sort |
Amal Amaghnouje |
title |
Subacute Assessment of the Toxicity and Antidepressant-Like Effects of <i>Origanum Majorana</i> L. Polyphenols in Swiss Albino Mice |
title_short |
Subacute Assessment of the Toxicity and Antidepressant-Like Effects of <i>Origanum Majorana</i> L. Polyphenols in Swiss Albino Mice |
title_full |
Subacute Assessment of the Toxicity and Antidepressant-Like Effects of <i>Origanum Majorana</i> L. Polyphenols in Swiss Albino Mice |
title_fullStr |
Subacute Assessment of the Toxicity and Antidepressant-Like Effects of <i>Origanum Majorana</i> L. Polyphenols in Swiss Albino Mice |
title_full_unstemmed |
Subacute Assessment of the Toxicity and Antidepressant-Like Effects of <i>Origanum Majorana</i> L. Polyphenols in Swiss Albino Mice |
title_sort |
subacute assessment of the toxicity and antidepressant-like effects of <i>origanum majorana</i> l. polyphenols in swiss albino mice |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-11-01 |
description |
<i>Origanum majorana </i>L. is a plant commonly used in folk medicine to treat depression and several neurological disorders. This study aims to evaluate the antidepressant-like effect of the <i>Origanum majorana</i> L. polyphenols (OMP) obtained from the aerial parts using two different depression model tests: the forced swimming test (FST) and the tail suspension test (TST) in Swiss albino mice. The experiments were performed on days 1, 7, 14, and 21 with daily administration of different treatments. Two different doses were chosen for this study (50 and 100 mg/kg), and paroxetine was used as a positive control. Immobility as a consequence of the depression state was significantly reduced following the treatment with OMP, indicating an antidepressant effect. A subacute toxicity study was also performed following the Organization for Economic Co-operation and Development (OECD) Guidelines (407), showing no sign of toxicity for the studied doses. The phytochemical screening revealed the presence of 12 components, all belonging to polyphenols: arbutin, rosmarinic acid, ursolic acid, quercetin-3-<i>O</i>-glucoside, quercetin-7-<i>O</i>-glucuronic acid, luteolin-7-<i>O</i>-glucoside, kaempferol-3-0-glucuronic acid, Kaempferol-3-0-pentose, caffeic acid, catechin, quercetin, and rutin. These findings suggest that <i>O. majorana</i> has interesting antidepressant-like properties, which deserve further investigation. |
topic |
<i>Origanum majorana</i> L. polyphenols antidepressant-like forced swimming test tail suspension test OECD 407 |
url |
https://www.mdpi.com/1420-3049/25/23/5653 |
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