Significance of pigment epithelium-derived factor levels with angiotensin II type 1 receptor blockers in patients with successful coronary stent implantation
Pigment epithelium-derived factor (PEDF) and pentosidine have received growing attention as sensitive biomarkers of the progression of atherosclerosis. The present study was performed to evaluate the utility of these biomarkers for assessing the effects of angiotensin II type 1 receptor blockers (AR...
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2011-09-01
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Online Access: | https://doi.org/10.1177/1470320310391921 |
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doaj-84b2aedb92064d28ae2a827789bce3992021-05-03T01:52:24ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1470-32032011-09-011210.1177/1470320310391921Significance of pigment epithelium-derived factor levels with angiotensin II type 1 receptor blockers in patients with successful coronary stent implantationMakoto SugiharaShin-ichiro MiuraYosuke TakamiyaYoshihiro KiyaTadaaki ArimuraAtsushi IwataAkira KawamuraHiroaki NishikawaSho-ichi YamagishiKeijiro SakuPigment epithelium-derived factor (PEDF) and pentosidine have received growing attention as sensitive biomarkers of the progression of atherosclerosis. The present study was performed to evaluate the utility of these biomarkers for assessing the effects of angiotensin II type 1 receptor blockers (ARBs). Sixty-three patients with coronary artery disease (CAD) following successful stent implantation were divided into an ARB group ( n = 50), who initially received valsartan or olmesartan immediately following stent implantation, and a non-ARB group ( n = 13) according to their blood pressure (BP) at baseline. Measurement of BP and blood sampling was performed prior to (at baseline) and 6—8 months following stent implantation (at follow-up). There were no significant differences in the baseline characteristics between the groups. Although there were no differences in the percentage of diameter re-stenosis between the groups, the BP level in the ARB group at follow-up showed a significant reduction and reached the target BP. The levels of plasma PEDF were significantly increased at follow-up in the ARB group, but not in the non-ARB group, while there were no differences in the levels of pentosidine between the groups. Changes in BP (ΔBP = BP at follow-up minus BP at baseline) were not associated with ΔPEDF. In conclusion, PEDF may be a useful biomarker for assessing the effects of ARBs independent of a reduction in BP.https://doi.org/10.1177/1470320310391921 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Makoto Sugihara Shin-ichiro Miura Yosuke Takamiya Yoshihiro Kiya Tadaaki Arimura Atsushi Iwata Akira Kawamura Hiroaki Nishikawa Sho-ichi Yamagishi Keijiro Saku |
spellingShingle |
Makoto Sugihara Shin-ichiro Miura Yosuke Takamiya Yoshihiro Kiya Tadaaki Arimura Atsushi Iwata Akira Kawamura Hiroaki Nishikawa Sho-ichi Yamagishi Keijiro Saku Significance of pigment epithelium-derived factor levels with angiotensin II type 1 receptor blockers in patients with successful coronary stent implantation Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Makoto Sugihara Shin-ichiro Miura Yosuke Takamiya Yoshihiro Kiya Tadaaki Arimura Atsushi Iwata Akira Kawamura Hiroaki Nishikawa Sho-ichi Yamagishi Keijiro Saku |
author_sort |
Makoto Sugihara |
title |
Significance of pigment epithelium-derived factor levels with angiotensin II type 1 receptor blockers in patients with successful coronary stent implantation |
title_short |
Significance of pigment epithelium-derived factor levels with angiotensin II type 1 receptor blockers in patients with successful coronary stent implantation |
title_full |
Significance of pigment epithelium-derived factor levels with angiotensin II type 1 receptor blockers in patients with successful coronary stent implantation |
title_fullStr |
Significance of pigment epithelium-derived factor levels with angiotensin II type 1 receptor blockers in patients with successful coronary stent implantation |
title_full_unstemmed |
Significance of pigment epithelium-derived factor levels with angiotensin II type 1 receptor blockers in patients with successful coronary stent implantation |
title_sort |
significance of pigment epithelium-derived factor levels with angiotensin ii type 1 receptor blockers in patients with successful coronary stent implantation |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1470-3203 |
publishDate |
2011-09-01 |
description |
Pigment epithelium-derived factor (PEDF) and pentosidine have received growing attention as sensitive biomarkers of the progression of atherosclerosis. The present study was performed to evaluate the utility of these biomarkers for assessing the effects of angiotensin II type 1 receptor blockers (ARBs). Sixty-three patients with coronary artery disease (CAD) following successful stent implantation were divided into an ARB group ( n = 50), who initially received valsartan or olmesartan immediately following stent implantation, and a non-ARB group ( n = 13) according to their blood pressure (BP) at baseline. Measurement of BP and blood sampling was performed prior to (at baseline) and 6—8 months following stent implantation (at follow-up). There were no significant differences in the baseline characteristics between the groups. Although there were no differences in the percentage of diameter re-stenosis between the groups, the BP level in the ARB group at follow-up showed a significant reduction and reached the target BP. The levels of plasma PEDF were significantly increased at follow-up in the ARB group, but not in the non-ARB group, while there were no differences in the levels of pentosidine between the groups. Changes in BP (ΔBP = BP at follow-up minus BP at baseline) were not associated with ΔPEDF. In conclusion, PEDF may be a useful biomarker for assessing the effects of ARBs independent of a reduction in BP. |
url |
https://doi.org/10.1177/1470320310391921 |
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