Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome
Health-related quality of life (HRQoL) is a multidimensional concept involving physical, psychological, social, and cognitive aspects of life. Individuals with Fragile X syndrome (FXS) experience a life-long disorder that impacts the HRQoL of the affected individual and their family. Thus, HRQoL may...
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doaj-84b30d56298142c3aea558d4045c2bfc2020-11-25T03:37:14ZengMDPI AGBrain Sciences2076-34252020-04-011021321310.3390/brainsci10040213Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X SyndromeMarika C. Coffman0Rebecca C. Shaffer1Lauren M. Schmitt2Kelli C. Dominick3Ernest Pedapati4Angel Wang5Elizabeth Berry-Kravis6Nicole Tartaglia7Craig A. Erickson8Division of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Developmental and Behavioral Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADepartments of Pediatrics, Rush University Medical Center, Chicago, IL 60612, USADepartments of Pediatrics, Neurological Sciences, Biochemistry, Rush University Medical Center, Chicago, IL 60612, USADevelopmental Pediatrics, Children’s Hospital Colorado, Aurora, CO 80045, USADivision of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USAHealth-related quality of life (HRQoL) is a multidimensional concept involving physical, psychological, social, and cognitive aspects of life. Individuals with Fragile X syndrome (FXS) experience a life-long disorder that impacts the HRQoL of the affected individual and their family. Thus, HRQoL may be an important outcome measure following intervention. However, it is yet not known whether HRQoL concerns relate to observed impairments in FXS. In the present study, we examined the nature and degree of association between HRQoL and established measures of functioning in FXS using the Parent Report for Children version of the PedsQL 4.0 Generic Core Scales and Cognitive Functioning Scale. We observed significant relationships between HRQoL a nd measures of adaptive behavior, maladaptive behaviors, and social functioning. The present study has implications for treatment outcomes for clinical trials in FXS.https://www.mdpi.com/2076-3425/10/4/213fragile X syndromehealth-related quality of lifequality of lifeadaptive behavior |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marika C. Coffman Rebecca C. Shaffer Lauren M. Schmitt Kelli C. Dominick Ernest Pedapati Angel Wang Elizabeth Berry-Kravis Nicole Tartaglia Craig A. Erickson |
spellingShingle |
Marika C. Coffman Rebecca C. Shaffer Lauren M. Schmitt Kelli C. Dominick Ernest Pedapati Angel Wang Elizabeth Berry-Kravis Nicole Tartaglia Craig A. Erickson Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome Brain Sciences fragile X syndrome health-related quality of life quality of life adaptive behavior |
author_facet |
Marika C. Coffman Rebecca C. Shaffer Lauren M. Schmitt Kelli C. Dominick Ernest Pedapati Angel Wang Elizabeth Berry-Kravis Nicole Tartaglia Craig A. Erickson |
author_sort |
Marika C. Coffman |
title |
Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome |
title_short |
Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome |
title_full |
Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome |
title_fullStr |
Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome |
title_full_unstemmed |
Examination of Correlates to Health-Related Quality of Life in Individuals with Fragile X Syndrome |
title_sort |
examination of correlates to health-related quality of life in individuals with fragile x syndrome |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2020-04-01 |
description |
Health-related quality of life (HRQoL) is a multidimensional concept involving physical, psychological, social, and cognitive aspects of life. Individuals with Fragile X syndrome (FXS) experience a life-long disorder that impacts the HRQoL of the affected individual and their family. Thus, HRQoL may be an important outcome measure following intervention. However, it is yet not known whether HRQoL concerns relate to observed impairments in FXS. In the present study, we examined the nature and degree of association between HRQoL and established measures of functioning in FXS using the Parent Report for Children version of the PedsQL 4.0 Generic Core Scales and Cognitive Functioning Scale. We observed significant relationships between HRQoL a nd measures of adaptive behavior, maladaptive behaviors, and social functioning. The present study has implications for treatment outcomes for clinical trials in FXS. |
topic |
fragile X syndrome health-related quality of life quality of life adaptive behavior |
url |
https://www.mdpi.com/2076-3425/10/4/213 |
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