Computational modeling of stem and progenitor cell kinetics identifies plausible hematopoietic lineage hierarchies
Summary: Classically, hematopoietic stem cell (HSC) differentiation is assumed to occur via progenitor compartments of decreasing plasticity and increasing maturity in a specific, hierarchical manner. The classical hierarchy has been challenged in the past by alternative differentiation pathways. We...
Main Authors: | Lisa Bast, Michèle C. Buck, Judith S. Hecker, Robert A.J. Oostendorp, Katharina S. Götze, Carsten Marr |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-02-01
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Series: | iScience |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221000882 |
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