CK-3, A Novel Methsulfonyl Pyridine Derivative, Suppresses Hepatocellular Carcinoma Proliferation and Invasion by Blocking the PI3K/AKT/mTOR and MAPK/ERK Pathways

CK-3, A Novel Methsulfonyl Pyridine Derivative, Suppresses Hepatocellular Carcinoma Proliferation and Invasion by Blocking the PI3K/AKT/mTOR and MAPK/ERK Pathways

Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor prognosis that highly expresses phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (ERK). The PI3K/AKT/mTOR and MAPK/ERK signaling pathways play a crucial role in HCC tumor formation, cell cycle, apoptosis and s...

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Bibliographic Details
Main Authors: Qiong Wu, Tian-yi Liu, Bai-chun Hu, Xiang Li, Yu-ting Wu, Xiao-tong Sun, Xiao-wen Jiang, Shu Wang, Xiao-chun Qin, Huai-wei Ding, Qing-chun Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma
proliferation
PI3K/AKT/mTOR
MAPK/ERK
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.717626/full

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