DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved]
Background: Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain...
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Wellcome
2019-02-01
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Series: | Wellcome Open Research |
Online Access: | https://wellcomeopenresearch.org/articles/3-63/v2 |
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doaj-84e0f3984daa4e8bb18ce89ed0e98599 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mathilde M.V. Pascal Andreas C. Themistocleous Ralf Baron Andreas Binder Didier Bouhassira Geert Crombez Nanna B. Finnerup Janne Gierthmühlen Yelena Granovsky Leif Groop Harry L. Hebert Troels S. Jensen Kristinn Johnsen Mark I. McCarthy Weihua Meng Colin N.A. Palmer Andrew S.C. Rice Jordi Serra Romà Solà David Yarnitsky Blair H. Smith Nadine Attal David L.H. Bennett |
spellingShingle |
Mathilde M.V. Pascal Andreas C. Themistocleous Ralf Baron Andreas Binder Didier Bouhassira Geert Crombez Nanna B. Finnerup Janne Gierthmühlen Yelena Granovsky Leif Groop Harry L. Hebert Troels S. Jensen Kristinn Johnsen Mark I. McCarthy Weihua Meng Colin N.A. Palmer Andrew S.C. Rice Jordi Serra Romà Solà David Yarnitsky Blair H. Smith Nadine Attal David L.H. Bennett DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved] Wellcome Open Research |
author_facet |
Mathilde M.V. Pascal Andreas C. Themistocleous Ralf Baron Andreas Binder Didier Bouhassira Geert Crombez Nanna B. Finnerup Janne Gierthmühlen Yelena Granovsky Leif Groop Harry L. Hebert Troels S. Jensen Kristinn Johnsen Mark I. McCarthy Weihua Meng Colin N.A. Palmer Andrew S.C. Rice Jordi Serra Romà Solà David Yarnitsky Blair H. Smith Nadine Attal David L.H. Bennett |
author_sort |
Mathilde M.V. Pascal |
title |
DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved] |
title_short |
DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved] |
title_full |
DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved] |
title_fullStr |
DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved] |
title_full_unstemmed |
DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved] |
title_sort |
dolorisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved] |
publisher |
Wellcome |
series |
Wellcome Open Research |
issn |
2398-502X |
publishDate |
2019-02-01 |
description |
Background: Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims to study these factors. Protocol: Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography. Ethics and dissemination: All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through the DOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations. Strengths and limitations: Large cohorts covering many possible triggers for neuropathic pain Multi-disciplinary approach to study the interaction of clinical, psychosocial and genetic risk factors High comparability of the data across centres thanks to harmonised protocols One limitation is that the length of the questionnaires might reduce the response rate and quality of responses of participants |
url |
https://wellcomeopenresearch.org/articles/3-63/v2 |
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doaj-84e0f3984daa4e8bb18ce89ed0e985992020-11-24T23:54:41ZengWellcomeWellcome Open Research2398-502X2019-02-01310.12688/wellcomeopenres.14576.216455DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain [version 2; referees: 2 approved]Mathilde M.V. Pascal0Andreas C. Themistocleous1Ralf Baron2Andreas Binder3Didier Bouhassira4Geert Crombez5Nanna B. Finnerup6Janne Gierthmühlen7Yelena Granovsky8Leif Groop9Harry L. Hebert10Troels S. Jensen11Kristinn Johnsen12Mark I. McCarthy13Weihua Meng14Colin N.A. Palmer15Andrew S.C. Rice16Jordi Serra17Romà Solà18David Yarnitsky19Blair H. Smith20Nadine Attal21David L.H. Bennett22Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UKNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UKDivision of Neurological Pain Research and Therapy, Department of Neurology, Universitätsklinikum Schleswig-Holstein, Kiel, 24105, GermanyDivision of Neurological Pain Research and Therapy, Department of Neurology, Universitätsklinikum Schleswig-Holstein, Kiel, 24105, GermanyINSERM U-987, Centre d'Evaluation et de Traitement de la Douleur, APHP, CHU Ambroise Paré, Boulogne-Billancourt, France and University Versailles Saint Quentin en Yvelines, Versailles, 78000, FranceDepartment of Experimental-Clinical and Health Psychology, Ghent University, Ghent, 9000, BelgiumDepartment of Clinical Medicine, Danish Pain Research Center, Aarhus University, Aarhus, 8000, DenmarkDivision of Neurological Pain Research and Therapy, Department of Neurology, Universitätsklinikum Schleswig-Holstein, Kiel, 24105, GermanyDepartment of Neurology, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa, IsraelDepartment of Clinical Sciences, Diabetes and Endocrinology, University of Lund, Malmö, SwedenDivision of Population Health Sciences, University of Dundee, Dundee, DD1 9SY, UKDepartment of Neurology, Aarhus University Hospital, Aarhus, 8200, DenmarkMentisCura, Reykjavik, 105, IcelandWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UKDivision of Population Health Sciences, University of Dundee, Dundee, DD1 9SY, UKCentre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, DD1 9SY, UKPain Research Group, Imperial College London, London, SW10 9NH, UKNeuroscience Technologies, Ltd, Barcelona, SpainNeuroscience Technologies, Ltd, Barcelona, SpainDepartment of Neurology, Rambam Health Care Campus, Technion Faculty of Medicine, Haifa, IsraelDivision of Population Health Sciences, University of Dundee, Dundee, DD1 9SY, UKINSERM U-987, Centre d'Evaluation et de Traitement de la Douleur, APHP, CHU Ambroise Paré, Boulogne-Billancourt, France and University Versailles Saint Quentin en Yvelines, Versailles, 78000, FranceNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UKBackground: Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims to study these factors. Protocol: Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography. Ethics and dissemination: All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through the DOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations. Strengths and limitations: Large cohorts covering many possible triggers for neuropathic pain Multi-disciplinary approach to study the interaction of clinical, psychosocial and genetic risk factors High comparability of the data across centres thanks to harmonised protocols One limitation is that the length of the questionnaires might reduce the response rate and quality of responses of participantshttps://wellcomeopenresearch.org/articles/3-63/v2 |