PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy
The photosensitizer (PS) as photodynamic therapy (PDT) agent, can also serve as the contrast agent for dual-modal fluorescence imaging (FLI) and photoacoustic imaging (PAI) for precise cancer theranostics. In this study, the PAI capability of commercial PS, benzoporphyrin derivative monoacid ring-A...
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2019-05-01
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doaj-84f5b831295c4bb0a56a423187e005642020-11-25T01:17:09ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052019-05-011231941003-11941003-910.1142/S179354581941003710.1142/S1793545819410037PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapyHao Xu0Yubin Liu1Junle Qu2Zhen Yuan3College of Optoelectronic Engineering, Shenzhen University, Key Laboratory of Optoelectronic, Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen, Guangdong, P. R. ChinaFaculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, P. R. ChinaCollege of Optoelectronic Engineering, Shenzhen University, Key Laboratory of Optoelectronic, Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen, Guangdong, P. R. ChinaFaculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, P. R. ChinaThe photosensitizer (PS) as photodynamic therapy (PDT) agent, can also serve as the contrast agent for dual-modal fluorescence imaging (FLI) and photoacoustic imaging (PAI) for precise cancer theranostics. In this study, the PAI capability of commercial PS, benzoporphyrin derivative monoacid ring-A (BPD) were examined and compared with that from the other PSs and dyes such as TPPS4, Cy5 dye and ICG. We discovered that BPD exhibited its advantage as contrast agent for PAI. Meanwhile, BPD can also serve as the contrast agent for enhanced FLI. In particular, the PEGylated nanoliposome (PNL) encapsulated BPD (LBPD) was produced for contrast enhanced dual-modal FLI and PAI and imaging-guided high-efficiency PDT. Enhanced FLI and PAI results demonstrated the significant accumulation of LBPD both within and among individual tumor during 24h monitoring for in vivo experiment tests. In-vitro and in-vivo PDT tests were also performed, which showed that LBPD have higher PDT efficiency and can easily break the blood vessel of tumor tissues as compared to that from BPD. It was discovered that LBPD has great potentials as a diagnosis and treatment agent for dual-modal FLI and PAI-guided PDT of cancer.http://www.worldscientific.com/doi/pdf/10.1142/S1793545819410037Liposomephotosensitizerphotodynamic therapyphotoacoustic imagingfluorescence imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hao Xu Yubin Liu Junle Qu Zhen Yuan |
spellingShingle |
Hao Xu Yubin Liu Junle Qu Zhen Yuan PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy Journal of Innovative Optical Health Sciences Liposome photosensitizer photodynamic therapy photoacoustic imaging fluorescence imaging |
author_facet |
Hao Xu Yubin Liu Junle Qu Zhen Yuan |
author_sort |
Hao Xu |
title |
PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy |
title_short |
PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy |
title_full |
PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy |
title_fullStr |
PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy |
title_full_unstemmed |
PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy |
title_sort |
pegylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy |
publisher |
World Scientific Publishing |
series |
Journal of Innovative Optical Health Sciences |
issn |
1793-5458 1793-7205 |
publishDate |
2019-05-01 |
description |
The photosensitizer (PS) as photodynamic therapy (PDT) agent, can also serve as the contrast agent for dual-modal fluorescence imaging (FLI) and photoacoustic imaging (PAI) for precise cancer theranostics. In this study, the PAI capability of commercial PS, benzoporphyrin derivative monoacid ring-A (BPD) were examined and compared with that from the other PSs and dyes such as TPPS4, Cy5 dye and ICG. We discovered that BPD exhibited its advantage as contrast agent for PAI. Meanwhile, BPD can also serve as the contrast agent for enhanced FLI. In particular, the PEGylated nanoliposome (PNL) encapsulated BPD (LBPD) was produced for contrast enhanced dual-modal FLI and PAI and imaging-guided high-efficiency PDT. Enhanced FLI and PAI results demonstrated the significant accumulation of LBPD both within and among individual tumor during 24h monitoring for in vivo experiment tests. In-vitro and in-vivo PDT tests were also performed, which showed that LBPD have higher PDT efficiency and can easily break the blood vessel of tumor tissues as compared to that from BPD. It was discovered that LBPD has great potentials as a diagnosis and treatment agent for dual-modal FLI and PAI-guided PDT of cancer. |
topic |
Liposome photosensitizer photodynamic therapy photoacoustic imaging fluorescence imaging |
url |
http://www.worldscientific.com/doi/pdf/10.1142/S1793545819410037 |
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