SUMOylation in Trypanosoma brucei

SUMOylation in Trypanosoma brucei

Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evi...

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Bibliographic Details
Main Authors: Cornelia Andrea Klein, Dorothea Droll, Christine Clayton
Format: Article
Language:English
Published: PeerJ Inc. 2013-10-01
Series:PeerJ
Subjects:
Trypanosoma brucei
SUMO
Heat shock
Oxidative stress
Small ubiquitin-like modifier
Online Access:https://peerj.com/articles/180.pdf
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spelling doaj-850527ccf49f45a8b664f988eba304212020-11-24T23:22:42ZengPeerJ Inc.PeerJ2167-83592013-10-011e18010.7717/peerj.180180SUMOylation in Trypanosoma bruceiCornelia Andrea Klein0Dorothea Droll1Christine Clayton2Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Heidelberg, GermanyZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Heidelberg, GermanyZentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Alliance, Heidelberg, GermanySmall ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evidence that trypanosome homologues of the SUMO conjugating enzyme Ubc9 (Tb927.2.2460) and the SUMO-specific protease SENP (Tb927.9.2220) are involved in SUMOylation and SUMO removal, respectively.https://peerj.com/articles/180.pdf Trypanosoma brucei SUMOHeat shockOxidative stressSmall ubiquitin-like modifier
collection DOAJ
language English
format Article
sources DOAJ
author Cornelia Andrea Klein
Dorothea Droll
Christine Clayton
spellingShingle Cornelia Andrea Klein
Dorothea Droll
Christine Clayton
SUMOylation in Trypanosoma brucei
PeerJ
Trypanosoma brucei
SUMO
Heat shock
Oxidative stress
Small ubiquitin-like modifier
author_facet Cornelia Andrea Klein
Dorothea Droll
Christine Clayton
author_sort Cornelia Andrea Klein
title SUMOylation in Trypanosoma brucei
title_short SUMOylation in Trypanosoma brucei
title_full SUMOylation in Trypanosoma brucei
title_fullStr SUMOylation in Trypanosoma brucei
title_full_unstemmed SUMOylation in Trypanosoma brucei
title_sort sumoylation in trypanosoma brucei
publisher PeerJ Inc.
series PeerJ
issn 2167-8359
publishDate 2013-10-01
description Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evidence that trypanosome homologues of the SUMO conjugating enzyme Ubc9 (Tb927.2.2460) and the SUMO-specific protease SENP (Tb927.9.2220) are involved in SUMOylation and SUMO removal, respectively.
topic Trypanosoma brucei
SUMO
Heat shock
Oxidative stress
Small ubiquitin-like modifier
url https://peerj.com/articles/180.pdf
work_keys_str_mv AT corneliaandreaklein sumoylationintrypanosomabrucei
AT dorotheadroll sumoylationintrypanosomabrucei
AT christineclayton sumoylationintrypanosomabrucei
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