Antiproliferative Effect and the Isolated Compounds of Pouzolzia indica

Antiproliferative Effect and the Isolated Compounds of Pouzolzia indica

Previous report showed the high potent antiproliferative effect of the methanolic part extracted from the aerial parts of Pouzolzia indica on NB4 and HT93A acute leukemic cell lines with the IC50 values of 28.5 and 49.8 μg/mL, respectively. The bioassay-guided fractionation of the methanolic part ga...

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Main Authors: Chanyapat Sangsuwon, Weena Jiratchariyakul, Yaowalak U-pratya, Tanawan Kummalue
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2013/342352
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spelling doaj-8506dc38648b4133b1fc93b0e78aa4ad2020-11-24T22:28:06ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/342352342352Antiproliferative Effect and the Isolated Compounds of Pouzolzia indicaChanyapat Sangsuwon0Weena Jiratchariyakul1Yaowalak U-pratya2Tanawan Kummalue3Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandDepartment of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, ThailandDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandPrevious report showed the high potent antiproliferative effect of the methanolic part extracted from the aerial parts of Pouzolzia indica on NB4 and HT93A acute leukemic cell lines with the IC50 values of 28.5 and 49.8 μg/mL, respectively. The bioassay-guided fractionation of the methanolic part gave 5 fractions, that is, FFI–FFV. FFII, FFIII, and FFIV inhibited the above leukemic cell lines with the IC50 values of 15.1 (FFII), 14.4 (FFIII), 32.1 (FFIV), and 31.0 (FFII), 9.7 (FFIII), 10.5 (FFIV) μg/mL, respectively. The compounds in these fractions were isolated using chromatographic technique. FFII contained friedelin 1, 28-hydroxy-3-friedelanone 2, and 7-methoxy-coumarin 3. FFIII contained 6, 7-dimethoxy-coumarin 4, scopoletin 5, methyl caffeate 6. FFIV contained sitosteryl glucoside 7 and a supposed glycosphingolipid 8. The chemical structures were elucidated by spectroscopic methods.http://dx.doi.org/10.1155/2013/342352
collection DOAJ
language English
format Article
sources DOAJ
author Chanyapat Sangsuwon
Weena Jiratchariyakul
Yaowalak U-pratya
Tanawan Kummalue
spellingShingle Chanyapat Sangsuwon
Weena Jiratchariyakul
Yaowalak U-pratya
Tanawan Kummalue
Antiproliferative Effect and the Isolated Compounds of Pouzolzia indica
Evidence-Based Complementary and Alternative Medicine
author_facet Chanyapat Sangsuwon
Weena Jiratchariyakul
Yaowalak U-pratya
Tanawan Kummalue
author_sort Chanyapat Sangsuwon
title Antiproliferative Effect and the Isolated Compounds of Pouzolzia indica
title_short Antiproliferative Effect and the Isolated Compounds of Pouzolzia indica
title_full Antiproliferative Effect and the Isolated Compounds of Pouzolzia indica
title_fullStr Antiproliferative Effect and the Isolated Compounds of Pouzolzia indica
title_full_unstemmed Antiproliferative Effect and the Isolated Compounds of Pouzolzia indica
title_sort antiproliferative effect and the isolated compounds of pouzolzia indica
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2013-01-01
description Previous report showed the high potent antiproliferative effect of the methanolic part extracted from the aerial parts of Pouzolzia indica on NB4 and HT93A acute leukemic cell lines with the IC50 values of 28.5 and 49.8 μg/mL, respectively. The bioassay-guided fractionation of the methanolic part gave 5 fractions, that is, FFI–FFV. FFII, FFIII, and FFIV inhibited the above leukemic cell lines with the IC50 values of 15.1 (FFII), 14.4 (FFIII), 32.1 (FFIV), and 31.0 (FFII), 9.7 (FFIII), 10.5 (FFIV) μg/mL, respectively. The compounds in these fractions were isolated using chromatographic technique. FFII contained friedelin 1, 28-hydroxy-3-friedelanone 2, and 7-methoxy-coumarin 3. FFIII contained 6, 7-dimethoxy-coumarin 4, scopoletin 5, methyl caffeate 6. FFIV contained sitosteryl glucoside 7 and a supposed glycosphingolipid 8. The chemical structures were elucidated by spectroscopic methods.
url http://dx.doi.org/10.1155/2013/342352
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