Mathematical Modeling Reveals the Role of Hypoxia in the Promotion of Human Mesenchymal Stem Cell Long-Term Expansion

Mathematical Modeling Reveals the Role of Hypoxia in the Promotion of Human Mesenchymal Stem Cell Long-Term Expansion

Many experimental studies have found that human mesenchymal stem cells (MSCs) in long-term culture exhibited enhanced cell proliferation and prolonged lifespan under hypoxia (around 1%–7% oxygen) against the normoxic condition (about 21% oxygen). Inspired by the experimental findings, we aimed to in...

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Bibliographic Details
Main Authors:	Shuhua Gao, Cheng Xiang, Kairong Qin, Changkai Sun
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2018/9283432

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