Interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasia
Interstitial granulomatous dermatitis (IGD) was first described in 1993 by Ackerman as a cutaneous reactive disease in patients with arthritis. Since then, numerous cases associated with different hematological and rheumatic disorders have been reported. IGD is a polymorphic entity that usually invo...
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doaj-850dad43c8eb41718d0b76211245fd1f2020-11-24T20:43:35ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112018-01-0163326426710.4103/ijd.IJD_432_17Interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasiaSandra Cases-MeridaAna Lorente-LavirgenAmalia Pérez-GilInterstitial granulomatous dermatitis (IGD) was first described in 1993 by Ackerman as a cutaneous reactive disease in patients with arthritis. Since then, numerous cases associated with different hematological and rheumatic disorders have been reported. IGD is a polymorphic entity that usually involves the upper part of the trunk. Histologically, it is defined as a diffuse dermal histiocytic infiltrate of different densities surrounded by fragmented collagen. We report the case of a 56-year-old man with pruritic papules affecting neck, proximal arms and thorax associated with weight loss and chronic fatigue for six months. Two punch biopsies were taken and the specimens showed lymphohistiocytic interstitial infiltrates with fragmented collagen and elastic fibers in dermis. IGD was diagnosed as first manifestation of a rare chronic myeloproliferative hematologic disorder (cMPD) with rearrangement of beta-receptor for platelet-derived growth factor (PDGFRB). After two months of imatinib, lesions regressed completely.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2018;volume=63;issue=3;spage=264;epage=267;aulast=Cases-MeridaHematological disordersimatinibinterstitial granulomatous dermatitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sandra Cases-Merida Ana Lorente-Lavirgen Amalia Pérez-Gil |
spellingShingle |
Sandra Cases-Merida Ana Lorente-Lavirgen Amalia Pérez-Gil Interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasia Indian Journal of Dermatology Hematological disorders imatinib interstitial granulomatous dermatitis |
author_facet |
Sandra Cases-Merida Ana Lorente-Lavirgen Amalia Pérez-Gil |
author_sort |
Sandra Cases-Merida |
title |
Interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasia |
title_short |
Interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasia |
title_full |
Interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasia |
title_fullStr |
Interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasia |
title_full_unstemmed |
Interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasia |
title_sort |
interstitial granulomatous dermatitis due to a rare myeloproliferative neoplasia |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Dermatology |
issn |
0019-5154 1998-3611 |
publishDate |
2018-01-01 |
description |
Interstitial granulomatous dermatitis (IGD) was first described in 1993 by Ackerman as a cutaneous reactive disease in patients with arthritis. Since then, numerous cases associated with different hematological and rheumatic disorders have been reported. IGD is a polymorphic entity that usually involves the upper part of the trunk. Histologically, it is defined as a diffuse dermal histiocytic infiltrate of different densities surrounded by fragmented collagen. We report the case of a 56-year-old man with pruritic papules affecting neck, proximal arms and thorax associated with weight loss and chronic fatigue for six months. Two punch biopsies were taken and the specimens showed lymphohistiocytic interstitial infiltrates with fragmented collagen and elastic fibers in dermis. IGD was diagnosed as first manifestation of a rare chronic myeloproliferative hematologic disorder (cMPD) with rearrangement of beta-receptor for platelet-derived growth factor (PDGFRB). After two months of imatinib, lesions regressed completely. |
topic |
Hematological disorders imatinib interstitial granulomatous dermatitis |
url |
http://www.e-ijd.org/article.asp?issn=0019-5154;year=2018;volume=63;issue=3;spage=264;epage=267;aulast=Cases-Merida |
work_keys_str_mv |
AT sandracasesmerida interstitialgranulomatousdermatitisduetoararemyeloproliferativeneoplasia AT analorentelavirgen interstitialgranulomatousdermatitisduetoararemyeloproliferativeneoplasia AT amaliaperezgil interstitialgranulomatousdermatitisduetoararemyeloproliferativeneoplasia |
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1716819476992753664 |