Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh

Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh

An enhancer named MFCS1 regulates Sonic hedgehog (Shh) expression in the posterior mesenchyme of limb buds. Several mutations in MFCS1 induce ectopic Shh expression in the anterior limb bud, and these result in preaxial polydactyly (PPD). However, the molecular basis of ectopic Shh expression remain...

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Bibliographic Details
Main Authors: Takanori Amano, Tomoko Sagai, Ryohei Seki, Toshihiko Shiroishi
Format: Article
Language:English
Published: Oxford University Press 2017-09-01
Series:G3: Genes, Genomes, Genetics
Subjects:
enhancer
gene regulation
preaxial polydactyly
Sonic hedgehog
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.117.044669

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