Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic act...
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Online Access: | https://doi.org/10.2478/amb-2021-0004 |
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doaj-852877ab5e974f5bb7a769ba1574c4592021-09-06T19:41:08ZengSciendoActa Medica Bulgarica0324-17502021-04-01481253310.2478/amb-2021-0004Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological PerspectivesAndreeva-Gateva P.0Tchekalarova J.1Kamenova K.2Strokova-Stoilova M.3Chakar S.4Hadjiolova R.5Angelova V. T.6Surcheva Sl.7Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaInstitute of Neurobiology, Bulgarian Academy of SciencesDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaDepartment of Pathophysiology, Faculty of Medicine, Medical University – Sofia, BulgariaDepartment of Chemistry, Faculty of Pharmacy, Medical University – Sofia, BulgariaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaAim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic activity of melatonin and two synthetic melatonin derivatives. The possible involvement of AhR and kynurenine in their neuropharmacological effects were also tested.https://doi.org/10.2478/amb-2021-0004melatoninindole derivativescorneal kindlinganalgesiaaryl hydrocarbon receptorskynurenine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andreeva-Gateva P. Tchekalarova J. Kamenova K. Strokova-Stoilova M. Chakar S. Hadjiolova R. Angelova V. T. Surcheva Sl. |
spellingShingle |
Andreeva-Gateva P. Tchekalarova J. Kamenova K. Strokova-Stoilova M. Chakar S. Hadjiolova R. Angelova V. T. Surcheva Sl. Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives Acta Medica Bulgarica melatonin indole derivatives corneal kindling analgesia aryl hydrocarbon receptors kynurenine |
author_facet |
Andreeva-Gateva P. Tchekalarova J. Kamenova K. Strokova-Stoilova M. Chakar S. Hadjiolova R. Angelova V. T. Surcheva Sl. |
author_sort |
Andreeva-Gateva P. |
title |
Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives |
title_short |
Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives |
title_full |
Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives |
title_fullStr |
Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives |
title_full_unstemmed |
Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives |
title_sort |
aryl hydrocarbon receptors in indole derivative treated mice: neuropharmacological perspectives |
publisher |
Sciendo |
series |
Acta Medica Bulgarica |
issn |
0324-1750 |
publishDate |
2021-04-01 |
description |
Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic activity of melatonin and two synthetic melatonin derivatives. The possible involvement of AhR and kynurenine in their neuropharmacological effects were also tested. |
topic |
melatonin indole derivatives corneal kindling analgesia aryl hydrocarbon receptors kynurenine |
url |
https://doi.org/10.2478/amb-2021-0004 |
work_keys_str_mv |
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