Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives

Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives

Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic act...

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Main Authors: Andreeva-Gateva P., Tchekalarova J., Kamenova K., Strokova-Stoilova M., Chakar S., Hadjiolova R., Angelova V. T., Surcheva Sl.
Format: Article
Language:English
Published: Sciendo 2021-04-01
Series:Acta Medica Bulgarica
Subjects:
melatonin
indole derivatives
corneal kindling
analgesia
aryl hydrocarbon receptors
kynurenine
Online Access:https://doi.org/10.2478/amb-2021-0004
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spelling doaj-852877ab5e974f5bb7a769ba1574c4592021-09-06T19:41:08ZengSciendoActa Medica Bulgarica0324-17502021-04-01481253310.2478/amb-2021-0004Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological PerspectivesAndreeva-Gateva P.0Tchekalarova J.1Kamenova K.2Strokova-Stoilova M.3Chakar S.4Hadjiolova R.5Angelova V. T.6Surcheva Sl.7Department of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaInstitute of Neurobiology, Bulgarian Academy of SciencesDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaDepartment of Pathophysiology, Faculty of Medicine, Medical University – Sofia, BulgariaDepartment of Chemistry, Faculty of Pharmacy, Medical University – Sofia, BulgariaDepartment of Pharmacology and Toxicology, Faculty of Medicine, Medical University – Sofia, BulgariaAim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic activity of melatonin and two synthetic melatonin derivatives. The possible involvement of AhR and kynurenine in their neuropharmacological effects were also tested.https://doi.org/10.2478/amb-2021-0004melatoninindole derivativescorneal kindlinganalgesiaaryl hydrocarbon receptorskynurenine
collection DOAJ
language English
format Article
sources DOAJ
author Andreeva-Gateva P.
Tchekalarova J.
Kamenova K.
Strokova-Stoilova M.
Chakar S.
Hadjiolova R.
Angelova V. T.
Surcheva Sl.
spellingShingle Andreeva-Gateva P.
Tchekalarova J.
Kamenova K.
Strokova-Stoilova M.
Chakar S.
Hadjiolova R.
Angelova V. T.
Surcheva Sl.
Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
Acta Medica Bulgarica
melatonin
indole derivatives
corneal kindling
analgesia
aryl hydrocarbon receptors
kynurenine
author_facet Andreeva-Gateva P.
Tchekalarova J.
Kamenova K.
Strokova-Stoilova M.
Chakar S.
Hadjiolova R.
Angelova V. T.
Surcheva Sl.
author_sort Andreeva-Gateva P.
title Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_short Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_full Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_fullStr Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_full_unstemmed Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_sort aryl hydrocarbon receptors in indole derivative treated mice: neuropharmacological perspectives
publisher Sciendo
series Acta Medica Bulgarica
issn 0324-1750
publishDate 2021-04-01
description Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic activity of melatonin and two synthetic melatonin derivatives. The possible involvement of AhR and kynurenine in their neuropharmacological effects were also tested.
topic melatonin
indole derivatives
corneal kindling
analgesia
aryl hydrocarbon receptors
kynurenine
url https://doi.org/10.2478/amb-2021-0004
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AT tchekalarovaj arylhydrocarbonreceptorsinindolederivativetreatedmiceneuropharmacologicalperspectives
AT kamenovak arylhydrocarbonreceptorsinindolederivativetreatedmiceneuropharmacologicalperspectives
AT strokovastoilovam arylhydrocarbonreceptorsinindolederivativetreatedmiceneuropharmacologicalperspectives
AT chakars arylhydrocarbonreceptorsinindolederivativetreatedmiceneuropharmacologicalperspectives
AT hadjiolovar arylhydrocarbonreceptorsinindolederivativetreatedmiceneuropharmacologicalperspectives
AT angelovavt arylhydrocarbonreceptorsinindolederivativetreatedmiceneuropharmacologicalperspectives
AT surchevasl arylhydrocarbonreceptorsinindolederivativetreatedmiceneuropharmacologicalperspectives
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