PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.

PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease.

Mutations in PTEN induced kinase 1 (PINK1), a mitochondrial Ser/Thr kinase, cause an autosomal recessive form of Parkinson's disease (PD), PARK6. Here, we report that PINK1 exists as a dimer in mitochondrial protein complexes that co-migrate with respiratory chain complexes in sucrose gradients...

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Bibliographic Details
Main Authors: Wencheng Liu, Cristofol Vives-Bauza, Rebeca Acín-Peréz-, Ai Yamamoto, Yingcai Tan, Yanping Li, Jordi Magrané, Mihaela A Stavarache, Sebastian Shaffer, Simon Chang, Michael G Kaplitt, Xin-Yun Huang, M Flint Beal, Giovanni Manfredi, Chenjian Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2644779?pdf=render

Internet

http://europepmc.org/articles/PMC2644779?pdf=render

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