The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review
BackgroundBone imbalance between anabolic and catabolic processes at the level of remodeling unit due to the prevalence of resorbing activity, represents a health problem of aging. The consequence is the negative balance of bone turnover that can lead to osteoporosis. Physical activity (PA) can play...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-10-01
|
Series: | Frontiers in Endocrinology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2020.585689/full |
id |
doaj-853283f2f8064a119b30d0176ed89e86 |
---|---|
record_format |
Article |
spelling |
doaj-853283f2f8064a119b30d0176ed89e862020-11-25T03:54:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-10-011110.3389/fendo.2020.585689585689The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic ReviewSofia Marini0Giuseppe Barone1Alice Masini2Laura Dallolio3Laura Bragonzoni4Yari Longobucco5Francesca Maffei6Department of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, ItalyDepartment of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, ItalyDepartment of Biomedical and Neuromotor Science, University of Bologna, Bologna, ItalyDepartment of Biomedical and Neuromotor Science, University of Bologna, Bologna, ItalyDepartment of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, ItalyClinical and Experimental Medicine Unit, Department of Medicine and Surgery, University of Parma, Parma, ItalyDepartment of Life Quality Studies, University of Bologna, Campus of Rimini, Rimini, ItalyBackgroundBone imbalance between anabolic and catabolic processes at the level of remodeling unit due to the prevalence of resorbing activity, represents a health problem of aging. The consequence is the negative balance of bone turnover that can lead to osteoporosis. Physical activity (PA) can play a central role in the comprehensive management of osteoporosis, since it induces the anabolism of bone tissue. Bone turnover biomarkers, reflecting the cellular activity linked to bone metabolism, can represent an evaluation tool to assess the efficacy of PA in the osteoporotic population. The aim of this systematic review, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, was to investigate the effects of PA interventions on bone biomarkers in people with osteoporosis.MethodsA comprehensive literature search of electronic databases was conducted through PubMed, Cochrane, Cinahl, Embase, Trip, to find randomized controlled trials (RCTs) investigating the topic of PA and bone turnover biomarkers in the osteoporosis population. In accordance with the Cochrane risk-of-bias tool, the quality of each study was assessed.ResultsOut of 992 identified articles, 136 full texts were screened. Only three RTCs matched the eligibility criteria. In one study, sub-maximal aerobic exercise improved Bone-specific alkaline phosphatase (bone formation biomarker) and Amino-terminal Crosslinked Telopeptide of type 1 collagen (bone resorption biomarker) in osteoporotic women. The other two studies showed a positive effect on total alkaline phosphatase (a non-specific bone formation biomarker) in women with osteoporosis.ConclusionThe systematic review revealed possible exercise benefits in terms of improving bone formation and decreasing bone resorption biomarkers in the osteoporotic population. However, these results should be interpreted with caution, especially due to the limited number and poor quality of the studies included. Further research is needed to estimate the influence of PA on bone biomarkers in the osteoporosis management.https://www.frontiersin.org/articles/10.3389/fendo.2020.585689/fullphysical activityexercisetrainingbone biomarkersosteoporosisbone metabolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sofia Marini Giuseppe Barone Alice Masini Laura Dallolio Laura Bragonzoni Yari Longobucco Francesca Maffei |
spellingShingle |
Sofia Marini Giuseppe Barone Alice Masini Laura Dallolio Laura Bragonzoni Yari Longobucco Francesca Maffei The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review Frontiers in Endocrinology physical activity exercise training bone biomarkers osteoporosis bone metabolism |
author_facet |
Sofia Marini Giuseppe Barone Alice Masini Laura Dallolio Laura Bragonzoni Yari Longobucco Francesca Maffei |
author_sort |
Sofia Marini |
title |
The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review |
title_short |
The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review |
title_full |
The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review |
title_fullStr |
The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review |
title_full_unstemmed |
The Effect of Physical Activity on Bone Biomarkers in People With Osteoporosis: A Systematic Review |
title_sort |
effect of physical activity on bone biomarkers in people with osteoporosis: a systematic review |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Endocrinology |
issn |
1664-2392 |
publishDate |
2020-10-01 |
description |
BackgroundBone imbalance between anabolic and catabolic processes at the level of remodeling unit due to the prevalence of resorbing activity, represents a health problem of aging. The consequence is the negative balance of bone turnover that can lead to osteoporosis. Physical activity (PA) can play a central role in the comprehensive management of osteoporosis, since it induces the anabolism of bone tissue. Bone turnover biomarkers, reflecting the cellular activity linked to bone metabolism, can represent an evaluation tool to assess the efficacy of PA in the osteoporotic population. The aim of this systematic review, conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, was to investigate the effects of PA interventions on bone biomarkers in people with osteoporosis.MethodsA comprehensive literature search of electronic databases was conducted through PubMed, Cochrane, Cinahl, Embase, Trip, to find randomized controlled trials (RCTs) investigating the topic of PA and bone turnover biomarkers in the osteoporosis population. In accordance with the Cochrane risk-of-bias tool, the quality of each study was assessed.ResultsOut of 992 identified articles, 136 full texts were screened. Only three RTCs matched the eligibility criteria. In one study, sub-maximal aerobic exercise improved Bone-specific alkaline phosphatase (bone formation biomarker) and Amino-terminal Crosslinked Telopeptide of type 1 collagen (bone resorption biomarker) in osteoporotic women. The other two studies showed a positive effect on total alkaline phosphatase (a non-specific bone formation biomarker) in women with osteoporosis.ConclusionThe systematic review revealed possible exercise benefits in terms of improving bone formation and decreasing bone resorption biomarkers in the osteoporotic population. However, these results should be interpreted with caution, especially due to the limited number and poor quality of the studies included. Further research is needed to estimate the influence of PA on bone biomarkers in the osteoporosis management. |
topic |
physical activity exercise training bone biomarkers osteoporosis bone metabolism |
url |
https://www.frontiersin.org/articles/10.3389/fendo.2020.585689/full |
work_keys_str_mv |
AT sofiamarini theeffectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT giuseppebarone theeffectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT alicemasini theeffectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT lauradallolio theeffectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT laurabragonzoni theeffectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT yarilongobucco theeffectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT francescamaffei theeffectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT sofiamarini effectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT giuseppebarone effectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT alicemasini effectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT lauradallolio effectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT laurabragonzoni effectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT yarilongobucco effectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview AT francescamaffei effectofphysicalactivityonbonebiomarkersinpeoplewithosteoporosisasystematicreview |
_version_ |
1724474620605628416 |