Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges
The design of zirconia-based scaffolds using conventional techniques for bone-regeneration applications has been studied extensively. Similar to dental applications, the use of three-dimensional (3D) zirconia-based ceramics for bone tissue engineering (BTE) has recently attracted considerable attent...
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doaj-8539d1c9975b4bc2bdf30ec62e61ea802021-06-30T23:51:39ZengMDPI AGMaterials1996-19442021-06-01143207320710.3390/ma14123207Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and ChallengesKumaresan Sakthiabirami0Vaiyapuri Soundharrajan1Jin-Ho Kang2Yunzhi Peter Yang3Sang-Won Park4Department of Prosthodontics, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, KoreaDepartment of Materials Science and Engineering, Chonnam National University, Gwangju 61186, KoreaDepartment of Prosthodontics, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, KoreaDepartment of Orthopaedics Surgery, Stanford University, Stanford, CA 94305-5110, USADepartment of Prosthodontics, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, KoreaThe design of zirconia-based scaffolds using conventional techniques for bone-regeneration applications has been studied extensively. Similar to dental applications, the use of three-dimensional (3D) zirconia-based ceramics for bone tissue engineering (BTE) has recently attracted considerable attention because of their high mechanical strength and biocompatibility. However, techniques to fabricate zirconia-based scaffolds for bone regeneration are in a stage of infancy. Hence, the biological activities of zirconia-based ceramics for bone-regeneration applications have not been fully investigated, in contrast to the well-established calcium phosphate-based ceramics for bone-regeneration applications. This paper outlines recent research developments and challenges concerning numerous three-dimensional (3D) zirconia-based scaffolds and reviews the associated fundamental fabrication techniques, key 3D fabrication developments and practical encounters to identify the optimal 3D fabrication technique for obtaining 3D zirconia-based scaffolds suitable for real-world applications. This review mainly summarized the articles that focused on in vitro and in vivo studies along with the fundamental mechanical characterizations on the 3D zirconia-based scaffolds.https://www.mdpi.com/1996-1944/14/12/32073D zirconia-based scaffoldbone-regeneration applicationscompositecoatingfabrication techniquesbioceramics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kumaresan Sakthiabirami Vaiyapuri Soundharrajan Jin-Ho Kang Yunzhi Peter Yang Sang-Won Park |
spellingShingle |
Kumaresan Sakthiabirami Vaiyapuri Soundharrajan Jin-Ho Kang Yunzhi Peter Yang Sang-Won Park Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges Materials 3D zirconia-based scaffold bone-regeneration applications composite coating fabrication techniques bioceramics |
author_facet |
Kumaresan Sakthiabirami Vaiyapuri Soundharrajan Jin-Ho Kang Yunzhi Peter Yang Sang-Won Park |
author_sort |
Kumaresan Sakthiabirami |
title |
Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges |
title_short |
Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges |
title_full |
Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges |
title_fullStr |
Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges |
title_full_unstemmed |
Three-Dimensional Zirconia-Based Scaffolds for Load-Bearing Bone-Regeneration Applications: Prospects and Challenges |
title_sort |
three-dimensional zirconia-based scaffolds for load-bearing bone-regeneration applications: prospects and challenges |
publisher |
MDPI AG |
series |
Materials |
issn |
1996-1944 |
publishDate |
2021-06-01 |
description |
The design of zirconia-based scaffolds using conventional techniques for bone-regeneration applications has been studied extensively. Similar to dental applications, the use of three-dimensional (3D) zirconia-based ceramics for bone tissue engineering (BTE) has recently attracted considerable attention because of their high mechanical strength and biocompatibility. However, techniques to fabricate zirconia-based scaffolds for bone regeneration are in a stage of infancy. Hence, the biological activities of zirconia-based ceramics for bone-regeneration applications have not been fully investigated, in contrast to the well-established calcium phosphate-based ceramics for bone-regeneration applications. This paper outlines recent research developments and challenges concerning numerous three-dimensional (3D) zirconia-based scaffolds and reviews the associated fundamental fabrication techniques, key 3D fabrication developments and practical encounters to identify the optimal 3D fabrication technique for obtaining 3D zirconia-based scaffolds suitable for real-world applications. This review mainly summarized the articles that focused on in vitro and in vivo studies along with the fundamental mechanical characterizations on the 3D zirconia-based scaffolds. |
topic |
3D zirconia-based scaffold bone-regeneration applications composite coating fabrication techniques bioceramics |
url |
https://www.mdpi.com/1996-1944/14/12/3207 |
work_keys_str_mv |
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