Efficacy of budesonide in treatment of acute exacerbation of chronic obstructive pulmonary disease

• Main Authors: Xue-Dong Chen, Jun Wei, Jun-Qing Ren, Xue-Fen Shuai, Ling Cheng, Dong-Gen Wu, Wei Wei, Jun Sun
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-06-01
• Series: Journal of Hainan Medical University
• Subjects: Budesonide; Chronic obstructive pulmonary disease; Acute exacerbation; Clinical efficacy
• Online Access: http://www.hnykdxxb.com/PDF/201611/8.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To explore the clinical efficacy of budesonide in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: A total of 60 patients with moderate and severe AECOPD who were admitted in our hospital from January, 2015 to January, 2016 were included in the study and randomized into the experiment group and the control group. The patients in the two groups were given oxygen inhalation, anti-infection, phlegm dispersing, ipratropium bromide (0.5 mg/time), and aerosol liquid of salbutamol sulfate (2.5 mg/time), 3 times/d, 20 min/time, aerosol inhalation. The patients in the experiment group were given budesonide (2 mg/time), while the patients in the control group were given budesonide (1 mg/time), every 8 h for one aerosol inhalation. The patients in the two groups were continuously treated for 7 d. The changes of PaO2, PaCO2, FEV1, and FEV1/FVC before and after treatment were detected, and the efficacy was evaluated. Results: After treatment, PaO2 and PaCO2 in the two groups were significantly improved when compared with before treatment, and the improved degree in the observation group was significantly superior to that in the control group. After treatment, FEV1 and FEV1/FVC in the two groups were significantly improved when compared with before treatment, and the improved degree in the observation group was significantly superior to that in the control group. The total effective rate in the observation group (93.33%) was significantly higher than that in the control group (76.67%). Conclusions: Aerosol inhalation of budesonide in the treatment of AECOPD in a large dose for a short term can significantly improve the blood gas and pulmonary function.