Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: a novel model for drug transport and hyperbilirubinemia disease

Characterization of organic anion transporting polypeptide 1b2 knockout rats generated by CRISPR/Cas9: a novel model for drug transport and hyperbilirubinemia disease

Organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1/3) as important uptake transporters play a fundamental role in the transportation of exogenous drugs and endogenous substances into cells. Rat OATP1B2, encoded by the Slco1b2 gene, is homologous to human OATP1B1/3. Although OATP1B1/3 is ver...

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Bibliographic Details
Main Authors: Xinrun Ma, Xuyang Shang, Xuan Qin, Jian Lu, Mingyao Liu, Xin Wang
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
OATP1B1/3
OATP1B2
CRISPR/Cas9
Transporter
Rat model
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519309098

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http://www.sciencedirect.com/science/article/pii/S2211383519309098

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