TAILOR – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial
Abstract Background The aim of the TAILOR trial is to investigate the effect of closely monitored tapering/discontinuation versus maintenance therapy with antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder and with minimum 3 months’ remission of...
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doaj-85497f0bc98a4f72964c32de60b76b6b2020-11-24T20:58:11ZengBMCTrials1745-62152017-09-0118111210.1186/s13063-017-2172-4TAILOR – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trialAnne Emilie Stürup0Heidi Dorthe Jensen1Signe Dolmer2Merete Birk3Nikolai Albert4Mai Nielsen5Carsten Hjorthøj6Lene Eplov7Bjørn H. Ebdrup8Ole Mors9Merete Nordentoft10Copenhagen University Hospital, Mental Health Center CopenhagenCopenhagen University Hospital, Mental Health Center CopenhagenPsychosis Research Unit, Aarhus University HospitalPsychosis Research Unit, Aarhus University HospitalCopenhagen University Hospital, Mental Health Center CopenhagenPsychosis Research Unit, Aarhus University HospitalCopenhagen University Hospital, Mental Health Center CopenhagenCopenhagen University Hospital, Mental Health Center CopenhagenCentre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Copenhagen University HospitalPsychosis Research Unit, Aarhus University HospitalCopenhagen University Hospital, Mental Health Center CopenhagenAbstract Background The aim of the TAILOR trial is to investigate the effect of closely monitored tapering/discontinuation versus maintenance therapy with antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder and with minimum 3 months’ remission of psychotic symptoms. Methods and design Two hundred and fifty patients will be included from the psychiatric early intervention program, OPUS, in two regions in Denmark. Inclusion criteria are: ICD-10 diagnoses schizophrenia (F20, except F20.6) or persistent delusional disorder (F22), minimum 3 months’ remission of psychotic symptoms and in treatment with antipsychotic medication (except clozapine). The patients will be randomized to maintenance therapy or tapering/discontinuation with antipsychotic medication in a 1-year intervention. The tapering/discontinuation group will be using a smartphone application to monitor early warning signs of psychotic relapse. Patients will be assessed at baseline, 1-, 2- and 5-year follow-up regarding psychotic and negative symptoms, side-effects of antipsychotic medication, social functioning, cognitive functioning, perceived health status, patient satisfaction, substance and alcohol use, sexual functioning and quality of life. The primary outcome will be remission of psychotic symptoms and no antipsychotic medication after 1 year. Secondary outcome measures will include: co-occurrence of remission of psychotic symptoms and 0–1-mg haloperidol equivalents of antipsychotic medication after 1-year intervention; antipsychotic dose; antipsychotic side effects; negative symptoms; social functioning; cognitive functioning; and patient satisfaction. Exploratory outcomes will include remission, clinical recovery, substance and alcohol use, sexual functioning, quality of life, self-beliefs of coping and user experience of support from health workers. Safety measures will include death, admissions to psychiatric hospital, severe self-harm and psychotic relapses. Discussion The TAILOR trial will contribute knowledge about the effect of tapering/discontinuation of antipsychotic medication in the early phases of schizophrenia and related disorders and the results may guide future clinical treatment regimens of antipsychotic treatment. Trial registration EU Clinical Trials Register – EudraCT number: 2016-000565-23 . Registered on 5 February 2016.http://link.springer.com/article/10.1186/s13063-017-2172-4SchizophreniaFirst-episode psychosisEarly interventionAntipsychotic medicationDiscontinuationTapering |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anne Emilie Stürup Heidi Dorthe Jensen Signe Dolmer Merete Birk Nikolai Albert Mai Nielsen Carsten Hjorthøj Lene Eplov Bjørn H. Ebdrup Ole Mors Merete Nordentoft |
spellingShingle |
Anne Emilie Stürup Heidi Dorthe Jensen Signe Dolmer Merete Birk Nikolai Albert Mai Nielsen Carsten Hjorthøj Lene Eplov Bjørn H. Ebdrup Ole Mors Merete Nordentoft TAILOR – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial Trials Schizophrenia First-episode psychosis Early intervention Antipsychotic medication Discontinuation Tapering |
author_facet |
Anne Emilie Stürup Heidi Dorthe Jensen Signe Dolmer Merete Birk Nikolai Albert Mai Nielsen Carsten Hjorthøj Lene Eplov Bjørn H. Ebdrup Ole Mors Merete Nordentoft |
author_sort |
Anne Emilie Stürup |
title |
TAILOR – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial |
title_short |
TAILOR – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial |
title_full |
TAILOR – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial |
title_fullStr |
TAILOR – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial |
title_full_unstemmed |
TAILOR – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial |
title_sort |
tailor – tapered discontinuation versus maintenance therapy of antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder in remission of psychotic symptoms: study protocol for a randomized clinical trial |
publisher |
BMC |
series |
Trials |
issn |
1745-6215 |
publishDate |
2017-09-01 |
description |
Abstract Background The aim of the TAILOR trial is to investigate the effect of closely monitored tapering/discontinuation versus maintenance therapy with antipsychotic medication in patients with newly diagnosed schizophrenia or persistent delusional disorder and with minimum 3 months’ remission of psychotic symptoms. Methods and design Two hundred and fifty patients will be included from the psychiatric early intervention program, OPUS, in two regions in Denmark. Inclusion criteria are: ICD-10 diagnoses schizophrenia (F20, except F20.6) or persistent delusional disorder (F22), minimum 3 months’ remission of psychotic symptoms and in treatment with antipsychotic medication (except clozapine). The patients will be randomized to maintenance therapy or tapering/discontinuation with antipsychotic medication in a 1-year intervention. The tapering/discontinuation group will be using a smartphone application to monitor early warning signs of psychotic relapse. Patients will be assessed at baseline, 1-, 2- and 5-year follow-up regarding psychotic and negative symptoms, side-effects of antipsychotic medication, social functioning, cognitive functioning, perceived health status, patient satisfaction, substance and alcohol use, sexual functioning and quality of life. The primary outcome will be remission of psychotic symptoms and no antipsychotic medication after 1 year. Secondary outcome measures will include: co-occurrence of remission of psychotic symptoms and 0–1-mg haloperidol equivalents of antipsychotic medication after 1-year intervention; antipsychotic dose; antipsychotic side effects; negative symptoms; social functioning; cognitive functioning; and patient satisfaction. Exploratory outcomes will include remission, clinical recovery, substance and alcohol use, sexual functioning, quality of life, self-beliefs of coping and user experience of support from health workers. Safety measures will include death, admissions to psychiatric hospital, severe self-harm and psychotic relapses. Discussion The TAILOR trial will contribute knowledge about the effect of tapering/discontinuation of antipsychotic medication in the early phases of schizophrenia and related disorders and the results may guide future clinical treatment regimens of antipsychotic treatment. Trial registration EU Clinical Trials Register – EudraCT number: 2016-000565-23 . Registered on 5 February 2016. |
topic |
Schizophrenia First-episode psychosis Early intervention Antipsychotic medication Discontinuation Tapering |
url |
http://link.springer.com/article/10.1186/s13063-017-2172-4 |
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