Coupling Genotyping and Computational Modeling in Prediction of Anti-epileptic Drugs that cause Stevens Johnson Syndrome and Toxic Epidermal Necrolysis for Carrier of HLA-B*15:02

Coupling Genotyping and Computational Modeling in Prediction of Anti-epileptic Drugs that cause Stevens Johnson Syndrome and Toxic Epidermal Necrolysis for Carrier of HLA-B*15:02

Purpose. The importance of HLA-B*15:02 genotyping to avoid carbamazepine induced SJS/TEN and molecular modeling to predict the role of HLA-B*15:0 and AEDs induced SJS/TEN are investigated. Methods. DNA was extracted from eighty-six patients. The patients were genotyped by AS-PCR. Computational mode...

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Main Authors: Lay Kek Teh, Manikandan Selvaraj, Zakaria Bannur, Mohd Ikhwan Mohd Ismail, Hanip Rafia, Wan Chung Law, Sapiah Sapuan, Santhi Puvanarajah, Pakeer Shaik Syed Ali, Mohd Zaki Salleh
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2016-03-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/25678

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