One-step sequence and structure-guided optimization of HIV-1 envelope gp140

One-step sequence and structure-guided optimization of HIV-1 envelope gp140

Stabilization of the metastable envelope glycoprotein (Env) of HIV-1 is hypothesized to improve induction of broadly neutralizing antibodies. We improved the expression yield and stability of the HIV-1 envelope glycoprotein BG505SOSIP.664 gp140 by means of a previously described automated sequence a...

Full description

Bibliographic Details
Main Authors: Sameer Kumar Malladi, David Schreiber, Ishika Pramanick, Malavika Abhineshababu Sridevi, Adi Goldenzweig, Somnath Dutta, Sarel Jacob Fleishman, Raghavan Varadarajan
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Current Research in Structural Biology
Subjects:
Rosetta
Protein stability
Protein design
Vaccine
Immunogen
Virus
Online Access:http://www.sciencedirect.com/science/article/pii/S2665928X20300052

Similar Items

Similar Items