Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individuals
<p>Abstract</p> <p>Background</p> <p>Recent refinements of lung MRI techniques have reduced the examination time and improved diagnostic sensitivity and specificity. We conducted a study to assess the feasibility of MRI for the detection of primary lung cancer in asympt...
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doaj-8562b42c031842f8bb162c2016aa247b2020-11-25T02:27:35ZengBMCBMC Cancer1471-24072011-06-0111124210.1186/1471-2407-11-242Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individualsKo James SCheng Hui-ChengWu Nai-YuanCheng Yu-ChenLin Po-WeiLin Wei-ChanChang Cheng-YenLiou Der-Ming<p>Abstract</p> <p>Background</p> <p>Recent refinements of lung MRI techniques have reduced the examination time and improved diagnostic sensitivity and specificity. We conducted a study to assess the feasibility of MRI for the detection of primary lung cancer in asymptomatic individuals.</p> <p>Methods</p> <p>A retrospective chart review was performed on images of lung parenchyma, which were extracted from whole-body MRI examinations between October 2000 and December 2007. 11,766 consecutive healthy individuals (mean age, 50.4 years; 56.8% male) were scanned using one of two 1.5-T scanners (Sonata and Sonata Maestro, Siemens Medical Solutions, Erlangen, Germany). The standard protocol included a quick whole-lung survey with T2-weighted 2-dimensional half Fourier acquisition single shot turbo spin echo (HASTE) and 3-dimensional volumetric interpolated breath-hold examination (VIBE). Total examination time was less than 10 minutes, and scanning time was only 5 minutes. Prompt referrals and follow-ups were arranged in cases of suspicious lung nodules.</p> <p>Results</p> <p>A total of 559 individuals (4.8%) had suspicious lung nodules. A total of 49 primary lung cancers were diagnosed in 46 individuals: 41 prevalence cancers and 8 incidence cancers. The overall detection rate of primary lung cancers was 0.4%. For smokers aged 51 to 70 years, the detection rate was 1.4%. TNM stage I disease accounted for 37 (75.5%). The mean size of detected lung cancers was 1.98 cm (median, 1.5 cm; range, 0.5-8.2 cm). The most histological types were adenocarcinoma in 38 (77.6%).</p> <p>Conclusion</p> <p>Rapid zero-dose MRI can be used for lung cancer detection in a healthy population.</p> http://www.biomedcentral.com/1471-2407/11/242 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ko James S Cheng Hui-Cheng Wu Nai-Yuan Cheng Yu-Chen Lin Po-Wei Lin Wei-Chan Chang Cheng-Yen Liou Der-Ming |
spellingShingle |
Ko James S Cheng Hui-Cheng Wu Nai-Yuan Cheng Yu-Chen Lin Po-Wei Lin Wei-Chan Chang Cheng-Yen Liou Der-Ming Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individuals BMC Cancer |
author_facet |
Ko James S Cheng Hui-Cheng Wu Nai-Yuan Cheng Yu-Chen Lin Po-Wei Lin Wei-Chan Chang Cheng-Yen Liou Der-Ming |
author_sort |
Ko James S |
title |
Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individuals |
title_short |
Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individuals |
title_full |
Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individuals |
title_fullStr |
Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individuals |
title_full_unstemmed |
Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individuals |
title_sort |
magnetic resonance imaging for lung cancer detection: experience in a population of more than 10,000 healthy individuals |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2011-06-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Recent refinements of lung MRI techniques have reduced the examination time and improved diagnostic sensitivity and specificity. We conducted a study to assess the feasibility of MRI for the detection of primary lung cancer in asymptomatic individuals.</p> <p>Methods</p> <p>A retrospective chart review was performed on images of lung parenchyma, which were extracted from whole-body MRI examinations between October 2000 and December 2007. 11,766 consecutive healthy individuals (mean age, 50.4 years; 56.8% male) were scanned using one of two 1.5-T scanners (Sonata and Sonata Maestro, Siemens Medical Solutions, Erlangen, Germany). The standard protocol included a quick whole-lung survey with T2-weighted 2-dimensional half Fourier acquisition single shot turbo spin echo (HASTE) and 3-dimensional volumetric interpolated breath-hold examination (VIBE). Total examination time was less than 10 minutes, and scanning time was only 5 minutes. Prompt referrals and follow-ups were arranged in cases of suspicious lung nodules.</p> <p>Results</p> <p>A total of 559 individuals (4.8%) had suspicious lung nodules. A total of 49 primary lung cancers were diagnosed in 46 individuals: 41 prevalence cancers and 8 incidence cancers. The overall detection rate of primary lung cancers was 0.4%. For smokers aged 51 to 70 years, the detection rate was 1.4%. TNM stage I disease accounted for 37 (75.5%). The mean size of detected lung cancers was 1.98 cm (median, 1.5 cm; range, 0.5-8.2 cm). The most histological types were adenocarcinoma in 38 (77.6%).</p> <p>Conclusion</p> <p>Rapid zero-dose MRI can be used for lung cancer detection in a healthy population.</p> |
url |
http://www.biomedcentral.com/1471-2407/11/242 |
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