Mutational Landscape of Virus- and UV-Associated Merkel Cell Carcinoma Cell Lines Is Comparable to Tumor Tissue

Mutational Landscape of Virus- and UV-Associated Merkel Cell Carcinoma Cell Lines Is Comparable to Tumor Tissue

Merkel cell carcinoma (MCC) is a rare, highly aggressive cutaneous malignancy that is either associated with the integration of the Merkel cell polyomavirus or chronic UV exposure. These two types of carcinogenesis are reflected in characteristic mutational features present in MCC tumor lesions. How...

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Bibliographic Details
Main Authors: Kai Horny, Patricia Gerhardt, Angela Hebel-Cherouny, Corinna Wülbeck, Jochen Utikal, Jürgen C. Becker
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
merkel cell carcinoma
merkel cell polyoma virus
UV
cell line
MYC
TP53
Online Access:https://www.mdpi.com/2072-6694/13/4/649

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