Tacrolimus-Induced Type IV Renal Tubular Acidosis following Liver Transplantation

Tacrolimus-Induced Type IV Renal Tubular Acidosis following Liver Transplantation

Calcineurin inhibitors remain an integral component of immunosuppressive therapy regimens following solid organ transplantation. Although nephrotoxicity associated with these agents is well documented, type IV renal tubular acidosis is a rare and potentially underreported complication following live...

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Main Authors: Christopher Schmoyer, Suraj Mishra, Frank Fulco
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Case Reports in Hepatology
Online Access:http://dx.doi.org/10.1155/2017/9312481
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spelling doaj-8574ccca72b14fc9a8eada831ad109462020-11-24T22:08:34ZengHindawi LimitedCase Reports in Hepatology2090-65872090-65952017-01-01201710.1155/2017/93124819312481Tacrolimus-Induced Type IV Renal Tubular Acidosis following Liver TransplantationChristopher Schmoyer0Suraj Mishra1Frank Fulco2Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USADepartment of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USADepartment of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USACalcineurin inhibitors remain an integral component of immunosuppressive therapy regimens following solid organ transplantation. Although nephrotoxicity associated with these agents is well documented, type IV renal tubular acidosis is a rare and potentially underreported complication following liver transplantation. Hepatologists must be able to recognize this adverse effect as it can lead to fatal hyperkalemia. We describe a case of tacrolimus-induced hyperkalemic type IV renal tubular acidosis in a patient following an orthotopic liver transplant for alcoholic cirrhosis.http://dx.doi.org/10.1155/2017/9312481
collection DOAJ
language English
format Article
sources DOAJ
author Christopher Schmoyer
Suraj Mishra
Frank Fulco
spellingShingle Christopher Schmoyer
Suraj Mishra
Frank Fulco
Tacrolimus-Induced Type IV Renal Tubular Acidosis following Liver Transplantation
Case Reports in Hepatology
author_facet Christopher Schmoyer
Suraj Mishra
Frank Fulco
author_sort Christopher Schmoyer
title Tacrolimus-Induced Type IV Renal Tubular Acidosis following Liver Transplantation
title_short Tacrolimus-Induced Type IV Renal Tubular Acidosis following Liver Transplantation
title_full Tacrolimus-Induced Type IV Renal Tubular Acidosis following Liver Transplantation
title_fullStr Tacrolimus-Induced Type IV Renal Tubular Acidosis following Liver Transplantation
title_full_unstemmed Tacrolimus-Induced Type IV Renal Tubular Acidosis following Liver Transplantation
title_sort tacrolimus-induced type iv renal tubular acidosis following liver transplantation
publisher Hindawi Limited
series Case Reports in Hepatology
issn 2090-6587
2090-6595
publishDate 2017-01-01
description Calcineurin inhibitors remain an integral component of immunosuppressive therapy regimens following solid organ transplantation. Although nephrotoxicity associated with these agents is well documented, type IV renal tubular acidosis is a rare and potentially underreported complication following liver transplantation. Hepatologists must be able to recognize this adverse effect as it can lead to fatal hyperkalemia. We describe a case of tacrolimus-induced hyperkalemic type IV renal tubular acidosis in a patient following an orthotopic liver transplant for alcoholic cirrhosis.
url http://dx.doi.org/10.1155/2017/9312481
work_keys_str_mv AT christopherschmoyer tacrolimusinducedtypeivrenaltubularacidosisfollowinglivertransplantation
AT surajmishra tacrolimusinducedtypeivrenaltubularacidosisfollowinglivertransplantation
AT frankfulco tacrolimusinducedtypeivrenaltubularacidosisfollowinglivertransplantation
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