Rheumatoid Factors: Clinical Applications
Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects. Rheumatoid factors form part...
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Online Access: | http://dx.doi.org/10.1155/2013/726598 |
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doaj-8585eeb8a7c6474ba229d994d580564b2020-11-24T22:17:02ZengHindawi LimitedDisease Markers0278-02401875-86302013-01-0135672773410.1155/2013/726598726598Rheumatoid Factors: Clinical ApplicationsFrancesca Ingegnoli0Roberto Castelli1Roberta Gualtierotti2Division of Rheumatology, Istituto Gaetano Pini, Department of Clinical Science & Community Health, University of Milan, 20122 Milan, ItalyInternal Medicine Section, IRCCS, Ca’ Granda Policlinico, Department of Pathophysiology and Transplation, University of Milan, 20122 Milan, ItalyDivision of Rheumatology, Istituto Gaetano Pini, Department of Clinical Science & Community Health, University of Milan, 20122 Milan, ItalyRheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects. Rheumatoid factors form part of the workup for the differential diagnosis of arthropathies. In clinical practice, it is recommended to measure anti-cyclic citrullinated peptide antibodies and rheumatoid factors together because anti-cyclic citrullinated peptide antibodies alone are only moderately sensitive, and the combination of the two markers improves diagnostic accuracy, especially in the case of early rheumatoid arthritis. Furthermore, different rheumatoid factor isotypes alone or in combination can be helpful when managing rheumatoid arthritis patients, from the time of diagnosis until deciding on the choice of therapeutic strategy.http://dx.doi.org/10.1155/2013/726598 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesca Ingegnoli Roberto Castelli Roberta Gualtierotti |
spellingShingle |
Francesca Ingegnoli Roberto Castelli Roberta Gualtierotti Rheumatoid Factors: Clinical Applications Disease Markers |
author_facet |
Francesca Ingegnoli Roberto Castelli Roberta Gualtierotti |
author_sort |
Francesca Ingegnoli |
title |
Rheumatoid Factors: Clinical Applications |
title_short |
Rheumatoid Factors: Clinical Applications |
title_full |
Rheumatoid Factors: Clinical Applications |
title_fullStr |
Rheumatoid Factors: Clinical Applications |
title_full_unstemmed |
Rheumatoid Factors: Clinical Applications |
title_sort |
rheumatoid factors: clinical applications |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2013-01-01 |
description |
Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects. Rheumatoid factors form part of the workup for the differential diagnosis of arthropathies. In clinical practice, it is recommended to measure anti-cyclic citrullinated peptide antibodies and rheumatoid factors together because anti-cyclic citrullinated peptide antibodies alone are only moderately sensitive, and the combination of the two markers improves diagnostic accuracy, especially in the case of early rheumatoid arthritis. Furthermore, different rheumatoid factor isotypes alone or in combination can be helpful when managing rheumatoid arthritis patients, from the time of diagnosis until deciding on the choice of therapeutic strategy. |
url |
http://dx.doi.org/10.1155/2013/726598 |
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AT francescaingegnoli rheumatoidfactorsclinicalapplications AT robertocastelli rheumatoidfactorsclinicalapplications AT robertagualtierotti rheumatoidfactorsclinicalapplications |
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