Gubenyiliu II Inhibits Breast Tumor Growth and Metastasis Associated with Decreased Heparanase Expression and Phosphorylation of ERK and AKT Pathways

Gubenyiliu II Inhibits Breast Tumor Growth and Metastasis Associated with Decreased Heparanase Expression and Phosphorylation of ERK and AKT Pathways

Gubenyiliu II (GYII), a Traditional Chinese Medicine (TCM) formula used in our hospital, has shown beneficial effects in cancer patients. In this study, we investigated the molecular mechanisms underlying the beneficial effects of GYII on murine breast cancer models. GYII showed significant inhibito...

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Bibliographic Details
Main Authors: Yi Zhang, Gan-Lin Zhang, Xu Sun, Ke-Xin Cao, Ya-Wen Shang, Mu-Xin Gong, Cong Ma, Nan Nan, Jin-Ping Li, Ming-Wei Yu, Guo-Wang Yang, Xiao-Min Wang
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:Molecules
Subjects:
Gubenyiliu II
breast tumor
heparanase
growth factors
ERK and AKT pathways
Online Access:http://www.mdpi.com/1420-3049/22/5/787

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