Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases
ABSTRACT Purpose: The objective of the study was to analyze the clinico-pathological differences and the oncologic outcomes between right and left-sided colon cancer. Patients and methods: The patients cohort was identified from a prospective register of colon cancer, 950 patients underwent surgery...
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doaj-85a672c8c6a84cbf9e741cafcb132eba2020-11-25T00:19:46ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-0108110313814410.17235/reed.2017.5034/2017S1130-01082018000300002Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 casesJavier-A. CienfuegosJorge BaixauliJorge ArredondoCarlos PastorPatricia Martínez-OrtegaGabriel ZozayaPablo Martí-CruchagaJosé-Luis Hernández-LizoáinABSTRACT Purpose: The objective of the study was to analyze the clinico-pathological differences and the oncologic outcomes between right and left-sided colon cancer. Patients and methods: The patients cohort was identified from a prospective register of colon cancer, 950 patients underwent surgery (stages I, II and III), of which 431 had right-sided colon cancer and 519 had left-sided colon cancer. Results: More laparoscopic resections were performed (101 vs 191; p < 0.001) and operating times were longer (146 min vs 165 min; p < 0.001) in the left-sided colon group. Patients with right-sided colon cancer more frequently received transfusions (18.8% vs 11.3%; p < 0.001) and experienced a greater number of complications (28.5% vs 20.9%, p = 0.004), although severity and operative mortality were similar in both groups (1.2% vs 0.2%). Mucinous adenocarcinomas and undifferentiated tumors were more frequent in the right-sided group (12% vs 6.5%; p < 0.001). Early stage was predominant in the left-sided colon tumors (28.2% vs 34.5%, p = 0.02). There were no differences in disease-free survival (DFS) in stages I and II after a median follow-up of 103 months. However, a greater survival at five and ten years in left-sided, stage III tumors was observed, with a trend towards statistical significance (p = 0.06). No differences were found with regard to the patterns of recurrence. Conclusions: Right-sided colon cancer exhibits phenotypical differences with regard to left-sided colon cancer. In stage III disease, left-sided colon cancer has a greater survival with a trend towards statistical significance. Overall, tumor location is a variable that should be taken into consideration in clinical studies of colon cancer.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082018000300002&lng=en&tlng=enColon neoplasmsColon descending/surgeryColon ascending/surgery,Adenocarcinoma/mortalityNeoplasm staging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Javier-A. Cienfuegos Jorge Baixauli Jorge Arredondo Carlos Pastor Patricia Martínez-Ortega Gabriel Zozaya Pablo Martí-Cruchaga José-Luis Hernández-Lizoáin |
spellingShingle |
Javier-A. Cienfuegos Jorge Baixauli Jorge Arredondo Carlos Pastor Patricia Martínez-Ortega Gabriel Zozaya Pablo Martí-Cruchaga José-Luis Hernández-Lizoáin Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases Revista Espanola de Enfermedades Digestivas Colon neoplasms Colon descending/surgery Colon ascending/surgery,Adenocarcinoma/mortality Neoplasm staging |
author_facet |
Javier-A. Cienfuegos Jorge Baixauli Jorge Arredondo Carlos Pastor Patricia Martínez-Ortega Gabriel Zozaya Pablo Martí-Cruchaga José-Luis Hernández-Lizoáin |
author_sort |
Javier-A. Cienfuegos |
title |
Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases |
title_short |
Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases |
title_full |
Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases |
title_fullStr |
Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases |
title_full_unstemmed |
Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases |
title_sort |
clinico-pathological and oncological differences between right and left-sided colon cancer (stages i-iii): analysis of 950 cases |
publisher |
Aran Ediciones |
series |
Revista Espanola de Enfermedades Digestivas |
issn |
1130-0108 |
description |
ABSTRACT Purpose: The objective of the study was to analyze the clinico-pathological differences and the oncologic outcomes between right and left-sided colon cancer. Patients and methods: The patients cohort was identified from a prospective register of colon cancer, 950 patients underwent surgery (stages I, II and III), of which 431 had right-sided colon cancer and 519 had left-sided colon cancer. Results: More laparoscopic resections were performed (101 vs 191; p < 0.001) and operating times were longer (146 min vs 165 min; p < 0.001) in the left-sided colon group. Patients with right-sided colon cancer more frequently received transfusions (18.8% vs 11.3%; p < 0.001) and experienced a greater number of complications (28.5% vs 20.9%, p = 0.004), although severity and operative mortality were similar in both groups (1.2% vs 0.2%). Mucinous adenocarcinomas and undifferentiated tumors were more frequent in the right-sided group (12% vs 6.5%; p < 0.001). Early stage was predominant in the left-sided colon tumors (28.2% vs 34.5%, p = 0.02). There were no differences in disease-free survival (DFS) in stages I and II after a median follow-up of 103 months. However, a greater survival at five and ten years in left-sided, stage III tumors was observed, with a trend towards statistical significance (p = 0.06). No differences were found with regard to the patterns of recurrence. Conclusions: Right-sided colon cancer exhibits phenotypical differences with regard to left-sided colon cancer. In stage III disease, left-sided colon cancer has a greater survival with a trend towards statistical significance. Overall, tumor location is a variable that should be taken into consideration in clinical studies of colon cancer. |
topic |
Colon neoplasms Colon descending/surgery Colon ascending/surgery,Adenocarcinoma/mortality Neoplasm staging |
url |
http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082018000300002&lng=en&tlng=en |
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