Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011.
Successful vaccination strategies against norovirus will require understanding the burden of disease and relevant genotypes in populations. However, few data are available from cohort studies of adults living in low- and middle-income countries (LMIC).We conducted a nested case-control study within...
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doaj-85aa1bad11f04664a7ab709e2b3fac4d2020-11-25T01:34:35ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013164610.1371/journal.pone.0131646Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011.Sarah-Blythe BallardErik J ReavesC Giannina LunaMaria E SilvaClaudio RochaKristen HeitzingerMayuko SaitoSonia ApazaSusan EspetiaDavid L BlazesDrake H TilleyRene C Guzmán AguilarRobert H GilmanDaniel G BauschSuccessful vaccination strategies against norovirus will require understanding the burden of disease and relevant genotypes in populations. However, few data are available from cohort studies of adults living in low- and middle-income countries (LMIC).We conducted a nested case-control study within a Peruvian military cohort to characterize the burden of norovirus infection, predominant genotypes, and associated symptoms from 2004 through 2011. Randomly selected case and control stools were tested for norovirus, bacteria, and parasites. The odds ratio of the association between norovirus infection and diarrhea was estimated using multiple logistic regression and co-infection adjusted attributable fractions were calculated.Of the 3,818 cohort study participants, 624 developed diarrhea. Overall and norovirus-associated diarrhea incidence rates were 42.3 and 6.0 per 100 person-years, respectively. The most prevalent norovirus genogroup was GII (72.5%, 29/40), which was associated with diarrhea (AOR 3.4, 95% CI: 1.3-8.7, P = 0.012). The co-infection adjusted GII attributable fraction was 6.4%.Norovirus was a frequent cause of diarrhea in an adult population followed longitudinally in an LMIC setting. Vaccine strategies should consider targeting adults in endemic settings and special populations that could serve as community transmission sources.http://europepmc.org/articles/PMC4498765?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sarah-Blythe Ballard Erik J Reaves C Giannina Luna Maria E Silva Claudio Rocha Kristen Heitzinger Mayuko Saito Sonia Apaza Susan Espetia David L Blazes Drake H Tilley Rene C Guzmán Aguilar Robert H Gilman Daniel G Bausch |
spellingShingle |
Sarah-Blythe Ballard Erik J Reaves C Giannina Luna Maria E Silva Claudio Rocha Kristen Heitzinger Mayuko Saito Sonia Apaza Susan Espetia David L Blazes Drake H Tilley Rene C Guzmán Aguilar Robert H Gilman Daniel G Bausch Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011. PLoS ONE |
author_facet |
Sarah-Blythe Ballard Erik J Reaves C Giannina Luna Maria E Silva Claudio Rocha Kristen Heitzinger Mayuko Saito Sonia Apaza Susan Espetia David L Blazes Drake H Tilley Rene C Guzmán Aguilar Robert H Gilman Daniel G Bausch |
author_sort |
Sarah-Blythe Ballard |
title |
Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011. |
title_short |
Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011. |
title_full |
Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011. |
title_fullStr |
Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011. |
title_full_unstemmed |
Epidemiology and Genetic Characterization of Noroviruses among Adults in an Endemic Setting, Peruvian Amazon Basin, 2004-2011. |
title_sort |
epidemiology and genetic characterization of noroviruses among adults in an endemic setting, peruvian amazon basin, 2004-2011. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Successful vaccination strategies against norovirus will require understanding the burden of disease and relevant genotypes in populations. However, few data are available from cohort studies of adults living in low- and middle-income countries (LMIC).We conducted a nested case-control study within a Peruvian military cohort to characterize the burden of norovirus infection, predominant genotypes, and associated symptoms from 2004 through 2011. Randomly selected case and control stools were tested for norovirus, bacteria, and parasites. The odds ratio of the association between norovirus infection and diarrhea was estimated using multiple logistic regression and co-infection adjusted attributable fractions were calculated.Of the 3,818 cohort study participants, 624 developed diarrhea. Overall and norovirus-associated diarrhea incidence rates were 42.3 and 6.0 per 100 person-years, respectively. The most prevalent norovirus genogroup was GII (72.5%, 29/40), which was associated with diarrhea (AOR 3.4, 95% CI: 1.3-8.7, P = 0.012). The co-infection adjusted GII attributable fraction was 6.4%.Norovirus was a frequent cause of diarrhea in an adult population followed longitudinally in an LMIC setting. Vaccine strategies should consider targeting adults in endemic settings and special populations that could serve as community transmission sources. |
url |
http://europepmc.org/articles/PMC4498765?pdf=render |
work_keys_str_mv |
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