Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: Impact of gender and immune status.
We examined trends in the MI incidence and age at MI diagnosis among adults living with HIV-1 between 2000 and 2009, by comparison with the French MI registries, by gender. Age standardized incidence rates and standardized incidence-ratios (SIRs) were estimated for individuals included in the French...
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doaj-85ab7cac49e44fc68f895402240384ad2021-03-03T20:57:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01141e021025310.1371/journal.pone.0210253Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: Impact of gender and immune status.Aliou BaldéSylvie LangAline WagnerJean FerrièresMichèle MontayePierre TattevinLaurent CotteElisabeth AslangulFrédéric BidégainAntoine ChéretMurielle Mary-KrauseJean-Luc MeynardJean-Michel MolinaMarialuisa PartisaniPierre-Marie RogerFranck BoccaraDominique CostagliolaWe examined trends in the MI incidence and age at MI diagnosis among adults living with HIV-1 between 2000 and 2009, by comparison with the French MI registries, by gender. Age standardized incidence rates and standardized incidence-ratios (SIRs) were estimated for individuals included in the French hospital database on HIV (n = 71 204, MI = 663) during three periods: 2000-2002, 2003-2005 and 2006-2009. Median ages at MI diagnosis were compared using the Brown-Mood test. Over the study periods, the absolute rate difference and relative risks were higher in women than in men in 2000-2002 and 2006-2009, with respective SIRs 1.99 (1.39-2.75) and 1.12 (0.99-1.27) in 2006-2009. The trends were different for men and women with a decreasing trend in SIRs in men and no change in women. In both sexes, among individuals with CD4 ≥500/μL and controlled viral-load on cART, the risk was no longer elevated. Age at MI diagnosis was significantly younger than in the general population, especially among women (-6.2 years, p<0.001; men: -2.1 years, p = 0.02). In HIV-1-positive adults, absolute rate difference and relative risks and trends of MI were different between men and women and there was no additional risk among individuals on effective cART.https://doi.org/10.1371/journal.pone.0210253 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aliou Baldé Sylvie Lang Aline Wagner Jean Ferrières Michèle Montaye Pierre Tattevin Laurent Cotte Elisabeth Aslangul Frédéric Bidégain Antoine Chéret Murielle Mary-Krause Jean-Luc Meynard Jean-Michel Molina Marialuisa Partisani Pierre-Marie Roger Franck Boccara Dominique Costagliola |
spellingShingle |
Aliou Baldé Sylvie Lang Aline Wagner Jean Ferrières Michèle Montaye Pierre Tattevin Laurent Cotte Elisabeth Aslangul Frédéric Bidégain Antoine Chéret Murielle Mary-Krause Jean-Luc Meynard Jean-Michel Molina Marialuisa Partisani Pierre-Marie Roger Franck Boccara Dominique Costagliola Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: Impact of gender and immune status. PLoS ONE |
author_facet |
Aliou Baldé Sylvie Lang Aline Wagner Jean Ferrières Michèle Montaye Pierre Tattevin Laurent Cotte Elisabeth Aslangul Frédéric Bidégain Antoine Chéret Murielle Mary-Krause Jean-Luc Meynard Jean-Michel Molina Marialuisa Partisani Pierre-Marie Roger Franck Boccara Dominique Costagliola |
author_sort |
Aliou Baldé |
title |
Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: Impact of gender and immune status. |
title_short |
Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: Impact of gender and immune status. |
title_full |
Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: Impact of gender and immune status. |
title_fullStr |
Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: Impact of gender and immune status. |
title_full_unstemmed |
Trends in the risk of myocardial infarction among HIV-1-infected individuals relative to the general population in France: Impact of gender and immune status. |
title_sort |
trends in the risk of myocardial infarction among hiv-1-infected individuals relative to the general population in france: impact of gender and immune status. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2019-01-01 |
description |
We examined trends in the MI incidence and age at MI diagnosis among adults living with HIV-1 between 2000 and 2009, by comparison with the French MI registries, by gender. Age standardized incidence rates and standardized incidence-ratios (SIRs) were estimated for individuals included in the French hospital database on HIV (n = 71 204, MI = 663) during three periods: 2000-2002, 2003-2005 and 2006-2009. Median ages at MI diagnosis were compared using the Brown-Mood test. Over the study periods, the absolute rate difference and relative risks were higher in women than in men in 2000-2002 and 2006-2009, with respective SIRs 1.99 (1.39-2.75) and 1.12 (0.99-1.27) in 2006-2009. The trends were different for men and women with a decreasing trend in SIRs in men and no change in women. In both sexes, among individuals with CD4 ≥500/μL and controlled viral-load on cART, the risk was no longer elevated. Age at MI diagnosis was significantly younger than in the general population, especially among women (-6.2 years, p<0.001; men: -2.1 years, p = 0.02). In HIV-1-positive adults, absolute rate difference and relative risks and trends of MI were different between men and women and there was no additional risk among individuals on effective cART. |
url |
https://doi.org/10.1371/journal.pone.0210253 |
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