Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico
Dendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM). PAMAM dendrimer used as a template in the preparation of gold nano...
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Mulawarman University
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doaj-85bc065de1b2450a9c70492a203145fe2020-11-24T20:40:43ZengMulawarman UniversityJournal of Tropical Pharmacy and Chemistry2087-70992407-60902017-07-0141354210.25026/jtpc.v4i1.130130Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In SilicoYurika SastyarinaZuhrotun NafisahMuhammad YusufMartalena RamliAbdul MutalibUkun SoedjanaatmadjaDendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM). PAMAM dendrimer used as a template in the preparation of gold nanoparticles. This research was studied the streched cavities of (Poly)amidoamine (PAMAM) dendrimer generation 4 using in silico method. Structure of (Poly) amidoamine (PAMAM) dendrimers generation 4 downloaded from Building Toolkit (DBT) Library and before the simulation structure was prepared. Then molecular dynamics simulations run using the AMBER program at 37°C in aqueous conditions. From analysis, obtained that the furthest distance of streched cavities at the closest distance from the core, region between residues 2 and 3 is 23.696 Å and at the terminal region between residues 100 and 122 is 58.045 Åhttps://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/130 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yurika Sastyarina Zuhrotun Nafisah Muhammad Yusuf Martalena Ramli Abdul Mutalib Ukun Soedjanaatmadja |
spellingShingle |
Yurika Sastyarina Zuhrotun Nafisah Muhammad Yusuf Martalena Ramli Abdul Mutalib Ukun Soedjanaatmadja Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico Journal of Tropical Pharmacy and Chemistry |
author_facet |
Yurika Sastyarina Zuhrotun Nafisah Muhammad Yusuf Martalena Ramli Abdul Mutalib Ukun Soedjanaatmadja |
author_sort |
Yurika Sastyarina |
title |
Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico |
title_short |
Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico |
title_full |
Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico |
title_fullStr |
Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico |
title_full_unstemmed |
Kajian Dendrimer (Poly)Amidoamine (Pamam) Generasi 4 Sebagai Template Dalam Pembentukan Nanopartikel Secara In Silico |
title_sort |
kajian dendrimer (poly)amidoamine (pamam) generasi 4 sebagai template dalam pembentukan nanopartikel secara in silico |
publisher |
Mulawarman University |
series |
Journal of Tropical Pharmacy and Chemistry |
issn |
2087-7099 2407-6090 |
publishDate |
2017-07-01 |
description |
Dendrimers are a class of highly branched synthetic polymers that has spherical form consist of three components: core, branch and terminal functional groups. One of dendrimer that has been commercialized is (Poly)amidoamine (PAMAM). PAMAM dendrimer used as a template in the preparation of gold nanoparticles. This research was studied the streched cavities of (Poly)amidoamine (PAMAM) dendrimer generation 4 using in silico method. Structure of (Poly) amidoamine (PAMAM) dendrimers generation 4 downloaded from Building Toolkit (DBT) Library and before the simulation structure was prepared. Then molecular dynamics simulations run using the AMBER program at 37°C in aqueous conditions. From analysis, obtained that the furthest distance of streched cavities at the closest distance from the core, region between residues 2 and 3 is 23.696 Å and at the terminal region between residues 100 and 122 is 58.045 Å |
url |
https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/130 |
work_keys_str_mv |
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