β-Amyloid Degradation and Alzheimer's Disease
Extensive β-amyloid (Aβ) deposits in brain parenchyma in the form of senile plaques and in blood vessels in the form of amyloid angiopathy are pathological hallmarks of Alzheimer's disease (AD). The mechanisms underlying Aβ deposition remain unclear. Major efforts have focused on Aβ production,...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2006-01-01
|
Series: | Journal of Biomedicine and Biotechnology |
Online Access: | http://dx.doi.org/10.1155/JBB/2006/58406 |
id |
doaj-85c16513fc3a42e486d0ec761778b332 |
---|---|
record_format |
Article |
spelling |
doaj-85c16513fc3a42e486d0ec761778b3322020-11-25T00:21:14ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512006-01-01200610.1155/JBB/2006/5840658406β-Amyloid Degradation and Alzheimer's DiseaseDeng-Shun Wang0Dennis W. Dickson1James S. Malter2Department of Pathology and Laboratory Medicine, School of Medicine, University of Wisconsin, Madison, WI 53705, USADepartments of Pathology (Neuropathology) and Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USADepartment of Pathology and Laboratory Medicine, School of Medicine, University of Wisconsin, Madison, WI 53705, USAExtensive β-amyloid (Aβ) deposits in brain parenchyma in the form of senile plaques and in blood vessels in the form of amyloid angiopathy are pathological hallmarks of Alzheimer's disease (AD). The mechanisms underlying Aβ deposition remain unclear. Major efforts have focused on Aβ production, but there is little to suggest that increased production of Aβ plays a role in Aβ deposition, except for rare familial forms of AD. Thus, other mechanisms must be involved in the accumulation of Aβ in AD. Recent data shows that impaired clearance may play an important role in Aβ accumulation in the pathogenesis of AD. This review focuses on our current knowledge of Aβ-degrading enzymes, including neprilysin (NEP), endothelin-converting enzyme (ECE), insulin-degrading enzyme (IDE), angiotensin-converting enzyme (ACE), and the plasmin/uPA/tPA system as they relate to amyloid deposition in AD.http://dx.doi.org/10.1155/JBB/2006/58406 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Deng-Shun Wang Dennis W. Dickson James S. Malter |
spellingShingle |
Deng-Shun Wang Dennis W. Dickson James S. Malter β-Amyloid Degradation and Alzheimer's Disease Journal of Biomedicine and Biotechnology |
author_facet |
Deng-Shun Wang Dennis W. Dickson James S. Malter |
author_sort |
Deng-Shun Wang |
title |
β-Amyloid Degradation and Alzheimer's Disease |
title_short |
β-Amyloid Degradation and Alzheimer's Disease |
title_full |
β-Amyloid Degradation and Alzheimer's Disease |
title_fullStr |
β-Amyloid Degradation and Alzheimer's Disease |
title_full_unstemmed |
β-Amyloid Degradation and Alzheimer's Disease |
title_sort |
β-amyloid degradation and alzheimer's disease |
publisher |
Hindawi Limited |
series |
Journal of Biomedicine and Biotechnology |
issn |
1110-7243 1110-7251 |
publishDate |
2006-01-01 |
description |
Extensive β-amyloid (Aβ) deposits in brain parenchyma
in the form of senile plaques and in blood vessels in the form of
amyloid angiopathy are pathological hallmarks of Alzheimer's
disease (AD). The mechanisms underlying Aβ deposition
remain unclear. Major efforts have focused on Aβ production,
but there is little to suggest that increased production of
Aβ plays a role in Aβ deposition, except for rare
familial forms of AD. Thus, other mechanisms must be involved in
the accumulation of Aβ in AD. Recent data shows that
impaired clearance may play an important role in Aβ
accumulation in the pathogenesis of AD. This review focuses on our
current knowledge of Aβ-degrading enzymes, including
neprilysin (NEP), endothelin-converting enzyme (ECE),
insulin-degrading enzyme (IDE), angiotensin-converting enzyme
(ACE), and the plasmin/uPA/tPA system as they relate to amyloid
deposition in AD. |
url |
http://dx.doi.org/10.1155/JBB/2006/58406 |
work_keys_str_mv |
AT dengshunwang bamyloiddegradationandalzheimersdisease AT denniswdickson bamyloiddegradationandalzheimersdisease AT jamessmalter bamyloiddegradationandalzheimersdisease |
_version_ |
1725363199481479168 |