Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice

Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice

Abstract Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network. Mutations such as D620N in the VPS35 gene have been identified in patients with autosomal dominant Parkinson’s...

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Main Authors: Sarivin Vanan, Xiaoxia Zeng, Sook Yoong Chia, Katarina Varnäs, Mei Jiang, Ke Zhang, Wuan Ting Saw, Parasuraman Padmanabhan, Wei-Ping Yu, Zhi-Dong Zhou, Christer Halldin, Balázs Gulyás, Eng-King Tan, Li Zeng
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Molecular Brain
Subjects:
Parkinson’s disease
VPS35 D620N
Striatal dopamine
Transgenic mice
Behavioral assay
Online Access:https://doi.org/10.1186/s13041-020-00704-3

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