Early hypophosphataemia in at risk newborns. Frequency and magnitude
Objective: To determine the frequency and magnitude of neonatal hypophosphataemia (<4 mg/dL) in a neonatal Intensive Care Unit and to describe risk groups. Patients and methods: Retrospective study of hospitalised newborns over a 44 month period (phase 1). Retrospective study of <1500 g/<32...
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Elsevier
2018-04-01
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Series: | Anales de Pediatría (English Edition) |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2341287918300255 |
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doaj-85c5e113bbca430d817e3e6811154e34 |
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Article |
collection |
DOAJ |
language |
Spanish |
format |
Article |
sources |
DOAJ |
author |
Gerardo Bustos Lozano Álvaro Hidalgo Romero Ana Melgar Bonis Noelia Ureta Velasco Carlos Orbea Gallardo Carmen Pallás Alonso |
spellingShingle |
Gerardo Bustos Lozano Álvaro Hidalgo Romero Ana Melgar Bonis Noelia Ureta Velasco Carlos Orbea Gallardo Carmen Pallás Alonso Early hypophosphataemia in at risk newborns. Frequency and magnitude Anales de Pediatría (English Edition) Hipofosforemia Nutrición parenteral Prematuridad Hipercalcemia Hipopotasemia Recién nacido |
author_facet |
Gerardo Bustos Lozano Álvaro Hidalgo Romero Ana Melgar Bonis Noelia Ureta Velasco Carlos Orbea Gallardo Carmen Pallás Alonso |
author_sort |
Gerardo Bustos Lozano |
title |
Early hypophosphataemia in at risk newborns. Frequency and magnitude |
title_short |
Early hypophosphataemia in at risk newborns. Frequency and magnitude |
title_full |
Early hypophosphataemia in at risk newborns. Frequency and magnitude |
title_fullStr |
Early hypophosphataemia in at risk newborns. Frequency and magnitude |
title_full_unstemmed |
Early hypophosphataemia in at risk newborns. Frequency and magnitude |
title_sort |
early hypophosphataemia in at risk newborns. frequency and magnitude |
publisher |
Elsevier |
series |
Anales de Pediatría (English Edition) |
issn |
2341-2879 |
publishDate |
2018-04-01 |
description |
Objective: To determine the frequency and magnitude of neonatal hypophosphataemia (<4 mg/dL) in a neonatal Intensive Care Unit and to describe risk groups. Patients and methods: Retrospective study of hospitalised newborns over a 44 month period (phase 1). Retrospective study of <1500 g/<32 weeks of gestation newborns over a 6 month period (phase 2). Prospective study of <1500 g or 1550–2000 g, and intrauterine growth restriction (IUGR) newborns. Measurements were made on the 1st, 3rd, 7th, and 14th days of life (phase 3). Results: Phase 1: 34 (2.4%) of 1,394 patients had a diagnosis of hypophosphataemia, 76% of them ≤32 weeks of gestation and <1500 g, and 24% >32 weeks with weight <P10. Phase 2: 12 (16.4%) of 73 patients had a diagnosis of hypophosphataemia, with <2 mg/dL in 5 (6.8%). Eight (75%) of those with hypophosphataemia had IUGR, and 4 (25%) weighed <1000 g. Five cases had associated hypokalaemia, and three hypercalcaemia. Phase 3: 9 (45%) of 20 patients had hypophosphataemia, all of them <1000 g or <1200 g and weight percentile <10. Thirty-three percent of samples on days 1, 3, and 7 showed hypophosphataemia, four of them <2 mg/dL. There was mild hypokalaemia in 5 (55%), and mild hypercalcaemia in 2 (22%) cases. Hypophosphataemia was associated with lower enteral nutrition and higher parenteral amino acid intake in the early days of life. Conclusions: Hypophosphataemia is common, and can be severe, in the first week of life in premature infants <1000 g, and newborns <1200 g with foetal malnutrition and receiving amino acids in early parenteral nutrition. Resumen: Objetivo: Conocer la frecuencia y la magnitud de la hipofosforemia neonatal (<4 mg/dl) en una UCIN y definir los grupos de riesgo. Pacientes y métodos: Estudio retrospectivo en neonatos hospitalizados, en periodo de 44 meses (fase 1). Estudio retrospectivo en <1.500 g/<32 semanas de gestación en período posterior de 6 meses (fase 2). Estudio prospectivo en <1.500 g o CIR con peso 1.500-2.000 g. Determinaciones en días 1, 3, 7 y 14 de vida (fase 3). Resultados: Fase 1: 34 de 1.394 pacientes (2,4%) fueron diagnosticados de hipofosforemia, 76% de ellos ≤32 semanas de gestación y <1.500 g, y 24% >32 semanas con peso <P10. Fase 2: 12 de 73 pacientes (16,4%) fueron diagnosticados de hipofosforemia, 5 (6,8%) con hipofosofremia <2 mg/dl. De ellos 8 fueron CIR y 4 <1.000 g. Cinco pacientes asociaron hipopotasemia y 3 hipercalcemia. Fase 3: 9 de 20 pacientes (45%) presentaron hipofosforemia, todos <1.000 g o con peso al nacer <1.200 g y percentil <10. El 33% de las muestras de los días 1, 3 y 7 mostraron hipofosforemia, <2 mg/dl en 4 muestras. Asociaron hipopotasemia leve 5 casos (55%) e hipercalcemia leve 2 (22%). La hipofosforemia se asoció a menor nutrición enteral y más aporte parenteral de aminoácidos en los primeros días. Conclusiones: La hipofosforemia es frecuente y puede ser crítica en la primera semana en prematuros <1.000 g y en los nacidos con desnutrición fetal y peso <1.200 g que reciben aminoácidos en la nutrición parenteral precoz. |
topic |
Hipofosforemia Nutrición parenteral Prematuridad Hipercalcemia Hipopotasemia Recién nacido |
url |
http://www.sciencedirect.com/science/article/pii/S2341287918300255 |
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doaj-85c5e113bbca430d817e3e6811154e342021-05-20T07:50:33ZspaElsevierAnales de Pediatría (English Edition)2341-28792018-04-01884216222Early hypophosphataemia in at risk newborns. Frequency and magnitudeGerardo Bustos Lozano0Álvaro Hidalgo Romero1Ana Melgar Bonis2Noelia Ureta Velasco3Carlos Orbea Gallardo4Carmen Pallás Alonso5Servicio de Neonatología, Hospital Universitario 12 de Octubre, Facultad de Medicina, Universidad Complutense de Madrid, Red SAMID del Instituto Carlos III, Instituto de Investigación Hospital Universitario 12 de Octubre, Madrid, Spain; Corresponding author.Facultad de Medicina, Universidad Complutense de Madrid, Madrid, SpainServicio de Neonatología, Hospital Universitario 12 de Octubre, Madrid, SpainServicio de Neonatología, Hospital Universitario 12 de Octubre, Madrid, SpainServicio de Neonatología, Hospital Universitario 12 de Octubre, Madrid, SpainServicio de Neonatología, Hospital Universitario 12 de Octubre, Facultad de Medicina, Universidad Complutense de Madrid, Red SAMID del Instituto Carlos III, Instituto de Investigación Hospital Universitario 12 de Octubre, Madrid, SpainObjective: To determine the frequency and magnitude of neonatal hypophosphataemia (<4 mg/dL) in a neonatal Intensive Care Unit and to describe risk groups. Patients and methods: Retrospective study of hospitalised newborns over a 44 month period (phase 1). Retrospective study of <1500 g/<32 weeks of gestation newborns over a 6 month period (phase 2). Prospective study of <1500 g or 1550–2000 g, and intrauterine growth restriction (IUGR) newborns. Measurements were made on the 1st, 3rd, 7th, and 14th days of life (phase 3). Results: Phase 1: 34 (2.4%) of 1,394 patients had a diagnosis of hypophosphataemia, 76% of them ≤32 weeks of gestation and <1500 g, and 24% >32 weeks with weight <P10. Phase 2: 12 (16.4%) of 73 patients had a diagnosis of hypophosphataemia, with <2 mg/dL in 5 (6.8%). Eight (75%) of those with hypophosphataemia had IUGR, and 4 (25%) weighed <1000 g. Five cases had associated hypokalaemia, and three hypercalcaemia. Phase 3: 9 (45%) of 20 patients had hypophosphataemia, all of them <1000 g or <1200 g and weight percentile <10. Thirty-three percent of samples on days 1, 3, and 7 showed hypophosphataemia, four of them <2 mg/dL. There was mild hypokalaemia in 5 (55%), and mild hypercalcaemia in 2 (22%) cases. Hypophosphataemia was associated with lower enteral nutrition and higher parenteral amino acid intake in the early days of life. Conclusions: Hypophosphataemia is common, and can be severe, in the first week of life in premature infants <1000 g, and newborns <1200 g with foetal malnutrition and receiving amino acids in early parenteral nutrition. Resumen: Objetivo: Conocer la frecuencia y la magnitud de la hipofosforemia neonatal (<4 mg/dl) en una UCIN y definir los grupos de riesgo. Pacientes y métodos: Estudio retrospectivo en neonatos hospitalizados, en periodo de 44 meses (fase 1). Estudio retrospectivo en <1.500 g/<32 semanas de gestación en período posterior de 6 meses (fase 2). Estudio prospectivo en <1.500 g o CIR con peso 1.500-2.000 g. Determinaciones en días 1, 3, 7 y 14 de vida (fase 3). Resultados: Fase 1: 34 de 1.394 pacientes (2,4%) fueron diagnosticados de hipofosforemia, 76% de ellos ≤32 semanas de gestación y <1.500 g, y 24% >32 semanas con peso <P10. Fase 2: 12 de 73 pacientes (16,4%) fueron diagnosticados de hipofosforemia, 5 (6,8%) con hipofosofremia <2 mg/dl. De ellos 8 fueron CIR y 4 <1.000 g. Cinco pacientes asociaron hipopotasemia y 3 hipercalcemia. Fase 3: 9 de 20 pacientes (45%) presentaron hipofosforemia, todos <1.000 g o con peso al nacer <1.200 g y percentil <10. El 33% de las muestras de los días 1, 3 y 7 mostraron hipofosforemia, <2 mg/dl en 4 muestras. Asociaron hipopotasemia leve 5 casos (55%) e hipercalcemia leve 2 (22%). La hipofosforemia se asoció a menor nutrición enteral y más aporte parenteral de aminoácidos en los primeros días. Conclusiones: La hipofosforemia es frecuente y puede ser crítica en la primera semana en prematuros <1.000 g y en los nacidos con desnutrición fetal y peso <1.200 g que reciben aminoácidos en la nutrición parenteral precoz.http://www.sciencedirect.com/science/article/pii/S2341287918300255HipofosforemiaNutrición parenteralPrematuridadHipercalcemiaHipopotasemiaRecién nacido |