Enhancement of Immune Effector Functions by Modulating IgG's Intrinsic Affinity for Target Antigen.
Antibody-mediated immune effector functions play an essential role in the anti-tumor efficacy of many therapeutic mAbs. While much of the effort to improve effector potency has focused on augmenting the interaction between the antibody-Fc and activating Fc-receptors expressed on immune cells, the ro...
Main Authors: | Yariv Mazor, Chunning Yang, M Jack Borrok, Joanne Ayriss, Karen Aherne, Herren Wu, William F Dall'Acqua |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4913924?pdf=render |
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