Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer

Loss of PIK3R1 in ovarian cancer is a common event, which provides opportunities for therapeutic intervention. Here, the authors show that the STAT3 and AKT signaling pathways are activated upon PIK3R1 loss and that, in mice, inhibitors of these pathways could block tumorigenesis.

Bibliographic Details
Main Authors:	Xinran Li, Victor C. Y. Mak, Yuan Zhou, Chao Wang, Esther S. Y. Wong, Rakesh Sharma, Yiling Lu, Annie N. Y. Cheung, Gordon B. Mills, Lydia W. T. Cheung
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08574-7

id	doaj-85e4150d1ad2485d83cd05457232c1ef
record_format	Article
spelling	doaj-85e4150d1ad2485d83cd05457232c1ef2021-05-11T11:44:10ZengNature Publishing GroupNature Communications2041-17232019-02-0110111610.1038/s41467-019-08574-7Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancerXinran Li0Victor C. Y. Mak1Yuan Zhou2Chao Wang3Esther S. Y. Wong4Rakesh Sharma5Yiling Lu6Annie N. Y. Cheung7Gordon B. Mills8Lydia W. T. Cheung9School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongSchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan UniversityDepartment of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong KongProteomics & Metabolomics Core Facility, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Systems Biology, University of Texas MD Anderson Cancer CenterDepartment of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong KongKnight Cancer Institute, Oregon Health & Science UniversitySchool of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong KongLoss of PIK3R1 in ovarian cancer is a common event, which provides opportunities for therapeutic intervention. Here, the authors show that the STAT3 and AKT signaling pathways are activated upon PIK3R1 loss and that, in mice, inhibitors of these pathways could block tumorigenesis.https://doi.org/10.1038/s41467-019-08574-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xinran Li Victor C. Y. Mak Yuan Zhou Chao Wang Esther S. Y. Wong Rakesh Sharma Yiling Lu Annie N. Y. Cheung Gordon B. Mills Lydia W. T. Cheung
spellingShingle	Xinran Li Victor C. Y. Mak Yuan Zhou Chao Wang Esther S. Y. Wong Rakesh Sharma Yiling Lu Annie N. Y. Cheung Gordon B. Mills Lydia W. T. Cheung Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer Nature Communications
author_facet	Xinran Li Victor C. Y. Mak Yuan Zhou Chao Wang Esther S. Y. Wong Rakesh Sharma Yiling Lu Annie N. Y. Cheung Gordon B. Mills Lydia W. T. Cheung
author_sort	Xinran Li
title	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_short	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_full	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_fullStr	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_full_unstemmed	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_sort	deregulated gab2 phosphorylation mediates aberrant akt and stat3 signaling upon pik3r1 loss in ovarian cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	Loss of PIK3R1 in ovarian cancer is a common event, which provides opportunities for therapeutic intervention. Here, the authors show that the STAT3 and AKT signaling pathways are activated upon PIK3R1 loss and that, in mice, inhibitors of these pathways could block tumorigenesis.
url	https://doi.org/10.1038/s41467-019-08574-7
work_keys_str_mv	AT xinranli deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer AT victorcymak deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer AT yuanzhou deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer AT chaowang deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer AT esthersywong deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer AT rakeshsharma deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer AT yilinglu deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer AT annienycheung deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer AT gordonbmills deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer AT lydiawtcheung deregulatedgab2phosphorylationmediatesaberrantaktandstat3signalinguponpik3r1lossinovariancancer
_version_	1721446084545347584

Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer

Similar Items