The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate
Chronic treatment with levodopa (LD) in Parkinson's disease (PD) can cause drug induced dyskinesias. Mucuna pruriens endocarp powder (MPEP) contains several compounds including natural LD and has been reported to not cause drug-induced dyskinesias. We evaluated the effects of Mucuna pruriens to...
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doaj-85e537b244c74565831cc7e56b4238392020-11-24T21:03:11ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882012-01-01201210.1155/2012/840247840247The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman PrimateChristopher A. Lieu0Kala Venkiteswaran1Timothy P. Gilmour2Anand N. Rao3Andrew C. Petticoffer4Erin V. Gilbert5Milind Deogaonkar6Bala V. Manyam7Thyagarajan Subramanian8Buck Institute for Research on Aging, Novato, CA 94945, USADepartment of Neurology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USADepartment of Neurology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USADepartment of Neurology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USADepartment of Neurology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USACenter for Neurological Restoration, The Cleveland Clinic Foundation, Cleveland, OH 44195, USACenter for Neurological Restoration, The Cleveland Clinic Foundation, Cleveland, OH 44195, USADepartment of Neurology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USADepartment of Neurology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USAChronic treatment with levodopa (LD) in Parkinson's disease (PD) can cause drug induced dyskinesias. Mucuna pruriens endocarp powder (MPEP) contains several compounds including natural LD and has been reported to not cause drug-induced dyskinesias. We evaluated the effects of Mucuna pruriens to determine if its underlying mechanistic actions are exclusively due to LD. We first compared MPEP with and without carbidopa (CD), and LD+CD in hemiparkinsonian (HP) monkeys. Each treatment ameliorated parkinsonism. We then compared the neuronal firing properties of the substantia nigra reticulata (SNR) and subthalamic nucleus (STN) in HP monkeys with MPEP+CD and LD+CD to evaluate basal ganglia circuitry alterations. Both treatments decreased SNR firing rate compared to HP state. However, LD+CD treatments significantly increased SNR bursting firing patterns that were not seen with MPEP+CD treatments. No significant changes were seen in STN firing properties. We then evaluated the effects of a water extract of MPEP. Oral MPWE ameliorated parkinsonism without causing drug-induced dyskinesias. The distinctive neurophysiological findings in the basal ganglia and the ability to ameliorate parkinsonism without causing dyskinesias strongly suggest that Mucuna pruriens acts through a novel mechanism that is different from that of LD.http://dx.doi.org/10.1155/2012/840247 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christopher A. Lieu Kala Venkiteswaran Timothy P. Gilmour Anand N. Rao Andrew C. Petticoffer Erin V. Gilbert Milind Deogaonkar Bala V. Manyam Thyagarajan Subramanian |
spellingShingle |
Christopher A. Lieu Kala Venkiteswaran Timothy P. Gilmour Anand N. Rao Andrew C. Petticoffer Erin V. Gilbert Milind Deogaonkar Bala V. Manyam Thyagarajan Subramanian The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate Evidence-Based Complementary and Alternative Medicine |
author_facet |
Christopher A. Lieu Kala Venkiteswaran Timothy P. Gilmour Anand N. Rao Andrew C. Petticoffer Erin V. Gilbert Milind Deogaonkar Bala V. Manyam Thyagarajan Subramanian |
author_sort |
Christopher A. Lieu |
title |
The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate |
title_short |
The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate |
title_full |
The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate |
title_fullStr |
The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate |
title_full_unstemmed |
The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate |
title_sort |
antiparkinsonian and antidyskinetic mechanisms of mucuna pruriens in the mptp-treated nonhuman primate |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2012-01-01 |
description |
Chronic treatment with levodopa (LD) in Parkinson's disease (PD) can cause drug induced dyskinesias. Mucuna pruriens endocarp powder (MPEP) contains several compounds including natural LD and has been reported to not cause drug-induced dyskinesias. We evaluated the effects of Mucuna pruriens to determine if its underlying mechanistic actions are exclusively due to LD. We first compared MPEP with and without carbidopa (CD), and LD+CD in hemiparkinsonian (HP) monkeys. Each treatment ameliorated parkinsonism. We then compared the neuronal firing properties of the substantia nigra reticulata (SNR) and subthalamic nucleus (STN) in HP monkeys with MPEP+CD and LD+CD to evaluate basal ganglia circuitry alterations. Both treatments decreased SNR firing rate compared to HP state. However, LD+CD treatments significantly increased SNR bursting firing patterns that were not seen with MPEP+CD treatments. No significant changes were seen in STN firing properties. We then evaluated the effects of a water extract of MPEP. Oral MPWE ameliorated parkinsonism without causing drug-induced dyskinesias. The distinctive neurophysiological findings in the basal ganglia and the ability to ameliorate parkinsonism without causing dyskinesias strongly suggest that Mucuna pruriens acts through a novel mechanism that is different from that of LD. |
url |
http://dx.doi.org/10.1155/2012/840247 |
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