Salivary Amylase as Potential Biochemical Marker in Diabetes Mellitus
Introduction: Diabetes mellitus has emerged as a major global health problem. Diagnosing and monitoring diabetes is the best way for its prevention, thus reducing the burden of disease. As saliva is easily available and accessible when compared with serum, salivary biomarkers have gained importance...
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doaj-85e7ca2e79214111836167bb619b5d952021-04-02T17:21:11ZengThieme Medical and Scientific Publishers Pvt. Ltd.International Journal of Recent Surgical and Medical Sciences2455-74202455-09492016-06-01020101902210.5005/jp-journals-10053-0005Salivary Amylase as Potential Biochemical Marker in Diabetes MellitusB NVS Satish Professor0Prashant Kumar Reader1S M Avanti Professor and Head2Shruti Singh Postgraduate Student3Department of Oral and Maxillofacial Pathology and Microbiology, S. Nijalingappa Institute of Dental Sciences & Research, Kalaburagi, Karnataka, IndiaDepartment of Oral and Maxillofacial Pathology and Microbiology, S. Nijalingappa Institute of Dental Sciences & Research, Kalaburagi, Karnataka, IndiaDepartment of Biochemistry, Mahadevappa Rampure Medical College, Kalaburagi, Karnataka, IndiaDepartment of Oral and Maxillofacial Pathology, S. Nijalingappa Institute of Dental Sciences & Research, Kalaburagi, Karnataka IndiaIntroduction: Diabetes mellitus has emerged as a major global health problem. Diagnosing and monitoring diabetes is the best way for its prevention, thus reducing the burden of disease. As saliva is easily available and accessible when compared with serum, salivary biomarkers have gained importance in recent years and, therefore, can be helpful in diagnosing the disease. Aims: The purpose of this study was to estimate the salivary amylase level in patients with types I and II diabetes mellitus and to correlate these findings with those of nondiabetic individuals in order to ascertain its value as a biochemical indicator for diagnosing and monitoring the patients. Materials and methods: Three groups of patients were selected for the present study. Group A: 20 nondiabetic, healthy individuals; group B: 20 type I diabetes mellitus patients; group C: 20 type II diabetes mellitus patients. Fasting and postprandial unstimulated saliva samples were collected and subjected for analysis of salivary amylase. Estimation of salivary amylase was determined by direct substrate method. Results: The mean fasting salivary amylase level for types I and II diabetic and nondiabetic individuals was 245.60, 239.10, and 149 U/dL respectively, whereas the mean postprandial salivary amylase was 257.35, 246.15, and 154.2 U/dL respectively. The mean value of variables was compared using Student's t test and one-way analysis of variance test. Conclusion: The mean salivary amylase level was significantly increased in both types I and II diabetic individuals as compared with healthy nondiabetic subjects (p < 0.05). However, there was no significant difference in the mean of types I and II diabetic patients.http://www.thieme-connect.de/DOI/DOI?10.5005/jp-journals-10053-0005salivasalivary amylasetype i diabetes mellitustype ii diabetes mellitus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
B NVS Satish Professor Prashant Kumar Reader S M Avanti Professor and Head Shruti Singh Postgraduate Student |
spellingShingle |
B NVS Satish Professor Prashant Kumar Reader S M Avanti Professor and Head Shruti Singh Postgraduate Student Salivary Amylase as Potential Biochemical Marker in Diabetes Mellitus International Journal of Recent Surgical and Medical Sciences saliva salivary amylase type i diabetes mellitus type ii diabetes mellitus |
author_facet |
B NVS Satish Professor Prashant Kumar Reader S M Avanti Professor and Head Shruti Singh Postgraduate Student |
author_sort |
B NVS Satish Professor |
title |
Salivary Amylase as Potential Biochemical Marker in Diabetes Mellitus |
title_short |
Salivary Amylase as Potential Biochemical Marker in Diabetes Mellitus |
title_full |
Salivary Amylase as Potential Biochemical Marker in Diabetes Mellitus |
title_fullStr |
Salivary Amylase as Potential Biochemical Marker in Diabetes Mellitus |
title_full_unstemmed |
Salivary Amylase as Potential Biochemical Marker in Diabetes Mellitus |
title_sort |
salivary amylase as potential biochemical marker in diabetes mellitus |
publisher |
Thieme Medical and Scientific Publishers Pvt. Ltd. |
series |
International Journal of Recent Surgical and Medical Sciences |
issn |
2455-7420 2455-0949 |
publishDate |
2016-06-01 |
description |
Introduction: Diabetes mellitus has emerged as a major global health problem. Diagnosing and monitoring diabetes is the best way for its prevention, thus reducing the burden of disease. As saliva is easily available and accessible when compared with serum, salivary biomarkers have gained importance in recent years and, therefore, can be helpful in diagnosing the disease.
Aims: The purpose of this study was to estimate the salivary amylase level in patients with types I and II diabetes mellitus and to correlate these findings with those of nondiabetic individuals in order to ascertain its value as a biochemical indicator for diagnosing and monitoring the patients.
Materials and methods: Three groups of patients were selected for the present study. Group A: 20 nondiabetic, healthy individuals; group B: 20 type I diabetes mellitus patients; group C: 20 type II diabetes mellitus patients. Fasting and postprandial unstimulated saliva samples were collected and subjected for analysis of salivary amylase. Estimation of salivary amylase was determined by direct substrate method.
Results: The mean fasting salivary amylase level for types I and II diabetic and nondiabetic individuals was 245.60, 239.10, and 149 U/dL respectively, whereas the mean postprandial salivary amylase was 257.35, 246.15, and 154.2 U/dL respectively. The mean value of variables was compared using Student's t test and one-way analysis of variance test.
Conclusion: The mean salivary amylase level was significantly increased in both types I and II diabetic individuals as compared with healthy nondiabetic subjects (p < 0.05). However, there was no significant difference in the mean of types I and II diabetic patients. |
topic |
saliva salivary amylase type i diabetes mellitus type ii diabetes mellitus |
url |
http://www.thieme-connect.de/DOI/DOI?10.5005/jp-journals-10053-0005 |
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