Enhanced mitochondrial pyruvate transport elicits a robust ROS production to sensitize the antitumor efficacy of interferon-γ in colon cancer

Enhanced mitochondrial pyruvate transport elicits a robust ROS production to sensitize the antitumor efficacy of interferon-γ in colon cancer

Metabolic reprogramming is a feature of cancer cells and crucial for tumor growth and metastasis. Interferon-γ (IFNγ) is a cytokine that plays a pivotal role in host antitumor immunity. However, little is known about the roles of metabolic reprogramming in immune responses. Here, we show that colon...

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Bibliographic Details
Main Authors:	YunYan Tai, Fengjun Cao, Mingxing Li, Pindong Li, Tao Xu, Xuanbin Wang, Yuandong Yu, Bing Gu, Xiongjie Yu, Xiaojun Cai, Feng Ao, Peng Ge, Longchao Xiang, Bingbing Yang, Yingpin Jiang, Yong Li
Format:	Article
Language:	English
Published:	Elsevier 2019-01-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231718307389

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