Dependence of NMDA/GSK-3β Mediated Metaplasticity on TRPM2 Channels at Hippocampal CA3-CA1 Synapses

Dependence of NMDA/GSK-3β Mediated Metaplasticity on TRPM2 Channels at Hippocampal CA3-CA1 Synapses

<p>Abstract</p> <p><it>Transient receptor potential melastatin 2 (TRPM2) is a calcium permeable non-selective cation channel that functions as a sensor of cellular redox status. Highly expressed within the CNS, we have previously demonstrated the functional expression of thes...

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Bibliographic Details
Main Authors: Xie Yu-Feng, Belrose Jillian C, Lei Gang, Tymianski Michael, Mori Yasuo, MacDonald John F, Jackson Michael F
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Molecular Brain
Subjects:
TRPM2
GSK-3β
PSD-95
Long term depression
Metaplasticity
NMDA Receptors
AMPA Receptors
Online Access:http://www.molecularbrain.com/content/4/1/44

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