Mechanisms Involved in Chemoresistance in Ovarian Cancer

Chemotherapy is a major treatment modality for ovarian cancer, but chemoresistance is a clinical problem that compromises the efficiency of treatment and finally results in treatment failure. The development of resistance to chemotherapeutic agents might be related to multiple mechanisms such as alt...

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Main Authors:	Kar-San Ling, Gin-Den Chen, Horng-Jyh Tsai, Maw-Sheng Lee, Po-Hui Wang
Format:	Article
Language:	English
Published:	Elsevier 2005-09-01
Series:	Taiwanese Journal of Obstetrics & Gynecology
Subjects:	chemoresistance chemotherapy ovarian cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S1028455909601431

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spelling	doaj-85f14c6a8da2468bb4141e5c7405bbb12020-11-24T21:18:18ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592005-09-0144320921710.1016/S1028-4559(09)60143-1Mechanisms Involved in Chemoresistance in Ovarian CancerKar-San LingGin-Den ChenHorng-Jyh TsaiMaw-Sheng LeePo-Hui WangChemotherapy is a major treatment modality for ovarian cancer, but chemoresistance is a clinical problem that compromises the efficiency of treatment and finally results in treatment failure. The development of resistance to chemotherapeutic agents might be related to multiple mechanisms such as alterations in drug transport, changes in cellular proteins involved in detoxification, altered drug target, changes in DNA repair mechanisms, and increased tolerance to drug-induced DNA damage. This article is a summary of the various mechanisms that are involved in chemoresistance in ovarian cancer.http://www.sciencedirect.com/science/article/pii/S1028455909601431chemoresistancechemotherapyovarian cancer
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kar-San Ling Gin-Den Chen Horng-Jyh Tsai Maw-Sheng Lee Po-Hui Wang
spellingShingle	Kar-San Ling Gin-Den Chen Horng-Jyh Tsai Maw-Sheng Lee Po-Hui Wang Mechanisms Involved in Chemoresistance in Ovarian Cancer Taiwanese Journal of Obstetrics & Gynecology chemoresistance chemotherapy ovarian cancer
author_facet	Kar-San Ling Gin-Den Chen Horng-Jyh Tsai Maw-Sheng Lee Po-Hui Wang
author_sort	Kar-San Ling
title	Mechanisms Involved in Chemoresistance in Ovarian Cancer
title_short	Mechanisms Involved in Chemoresistance in Ovarian Cancer
title_full	Mechanisms Involved in Chemoresistance in Ovarian Cancer
title_fullStr	Mechanisms Involved in Chemoresistance in Ovarian Cancer
title_full_unstemmed	Mechanisms Involved in Chemoresistance in Ovarian Cancer
title_sort	mechanisms involved in chemoresistance in ovarian cancer
publisher	Elsevier
series	Taiwanese Journal of Obstetrics & Gynecology
issn	1028-4559
publishDate	2005-09-01
description	Chemotherapy is a major treatment modality for ovarian cancer, but chemoresistance is a clinical problem that compromises the efficiency of treatment and finally results in treatment failure. The development of resistance to chemotherapeutic agents might be related to multiple mechanisms such as alterations in drug transport, changes in cellular proteins involved in detoxification, altered drug target, changes in DNA repair mechanisms, and increased tolerance to drug-induced DNA damage. This article is a summary of the various mechanisms that are involved in chemoresistance in ovarian cancer.
topic	chemoresistance chemotherapy ovarian cancer
url	http://www.sciencedirect.com/science/article/pii/S1028455909601431
work_keys_str_mv	AT karsanling mechanismsinvolvedinchemoresistanceinovariancancer AT gindenchen mechanismsinvolvedinchemoresistanceinovariancancer AT horngjyhtsai mechanismsinvolvedinchemoresistanceinovariancancer AT mawshenglee mechanismsinvolvedinchemoresistanceinovariancancer AT pohuiwang mechanismsinvolvedinchemoresistanceinovariancancer
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Mechanisms Involved in Chemoresistance in Ovarian Cancer

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