Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?

Prothrombotic states, similar to heparin-induced thrombocytopenia (HIT) in recipients of the ChAdOx vaccine, sounded alarm bells internationally. Equivalent episodes of HIT were detailed in several case reports of coronavirus disease 2019. This suggests a common pathogenesis and warrants a shift in...

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Main Authors:	A. AbdelMassih, R. Hozaien, M. El Shershaby, A. Kamel, H-A Ismail, R. Fouda
Format:	Article
Language:	English
Published:	Elsevier 2021-05-01
Series:	New Microbes and New Infections
Subjects:	Adenovirus mediated vaccines avoidance of heparin related anticoagulants ChAdOx vaccine COVID-19 PF4 antibodies thrombotic thrombocytopenic purpura
Online Access:	http://www.sciencedirect.com/science/article/pii/S2052297521000482

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spelling	doaj-85fba88f5ec34c0c839742aa204b01342021-06-03T04:56:25ZengElsevierNew Microbes and New Infections2052-29752021-05-0141100884Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?A. AbdelMassih0R. Hozaien1M. El Shershaby2A. Kamel3H-A Ismail4R. Fouda5Paediatric Cardiology Unit, Paediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt; Paediatric Cardio-Oncology Department, Children Cancer Hospital of Egypt, Cairo, Egypt; Corresponding author: A. AbdelMassih, Paediatric Department, Paediatric Cardiology Unit, Cairo University Children Hospital, Faculty of Medicine, Cairo University, Kasr Al Ainy Street, Cairo, Egypt.Research Accessibility Team, Student and Internship Research Programme, Faculty of Medicine, Cairo University, Cairo, EgyptResearch Accessibility Team, Student and Internship Research Programme, Faculty of Medicine, Cairo University, Cairo, EgyptResearch Accessibility Team, Student and Internship Research Programme, Faculty of Medicine, Cairo University, Cairo, EgyptResearch Accessibility Team, Student and Internship Research Programme, Faculty of Medicine, Cairo University, Cairo, EgyptClinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, EgyptProthrombotic states, similar to heparin-induced thrombocytopenia (HIT) in recipients of the ChAdOx vaccine, sounded alarm bells internationally. Equivalent episodes of HIT were detailed in several case reports of coronavirus disease 2019. This suggests a common pathogenesis and warrants a shift in the management of implicated cases.http://www.sciencedirect.com/science/article/pii/S2052297521000482Adenovirus mediated vaccinesavoidance of heparin related anticoagulantsChAdOx vaccineCOVID-19PF4 antibodiesthrombotic thrombocytopenic purpura
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	A. AbdelMassih R. Hozaien M. El Shershaby A. Kamel H-A Ismail R. Fouda
spellingShingle	A. AbdelMassih R. Hozaien M. El Shershaby A. Kamel H-A Ismail R. Fouda Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases? New Microbes and New Infections Adenovirus mediated vaccines avoidance of heparin related anticoagulants ChAdOx vaccine COVID-19 PF4 antibodies thrombotic thrombocytopenic purpura
author_facet	A. AbdelMassih R. Hozaien M. El Shershaby A. Kamel H-A Ismail R. Fouda
author_sort	A. AbdelMassih
title	Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?
title_short	Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?
title_full	Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?
title_fullStr	Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?
title_full_unstemmed	Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?
title_sort	is the heparin-induced thrombocytopenia-like syndrome associated with chadox vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?
publisher	Elsevier
series	New Microbes and New Infections
issn	2052-2975
publishDate	2021-05-01
description	Prothrombotic states, similar to heparin-induced thrombocytopenia (HIT) in recipients of the ChAdOx vaccine, sounded alarm bells internationally. Equivalent episodes of HIT were detailed in several case reports of coronavirus disease 2019. This suggests a common pathogenesis and warrants a shift in the management of implicated cases.
topic	Adenovirus mediated vaccines avoidance of heparin related anticoagulants ChAdOx vaccine COVID-19 PF4 antibodies thrombotic thrombocytopenic purpura
url	http://www.sciencedirect.com/science/article/pii/S2052297521000482
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Is the heparin-induced thrombocytopenia-like syndrome associated with ChAdOx vaccine related to the vaccine itself or to an autoimmune reaction to severe acute respiratory syndrome 2 coronavirus: insights and implications from previous reports in infected cases?

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