Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

Abstract Mitochondrial metabolism and the generation of reactive oxygen species (ROS) contribute to the acquisition of DNA mutations and genomic instability in cancer. How genomic instability influences the metabolic capacity of cancer cells is nevertheless poorly understood. Here, we show that homo...

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Bibliographic Details
Main Authors: Álvaro Lahiguera, Petra Hyroššová, Agnès Figueras, Diana Garzón, Roger Moreno, Vanessa Soto‐Cerrato, Iain McNeish, Violeta Serra, Conxi Lazaro, Pilar Barretina, Joan Brunet, Javier Menéndez, Xavier Matias‐Guiu, August Vidal, Alberto Villanueva, Barbie Taylor‐Harding, Hisashi Tanaka, Sandra Orsulic, Alexandra Junza, Oscar Yanes, Cristina Muñoz‐Pinedo, Luís Palomero, Miquel Àngel Pujana, José Carlos Perales, Francesc Viñals
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:EMBO Molecular Medicine
Subjects:
BCRA
cancer metabolism
metformin
OXPHOS
PARP inhibitors
Online Access:https://doi.org/10.15252/emmm.201911217

Internet

https://doi.org/10.15252/emmm.201911217

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