Meta-analysis on the treatment of diabetic nephropathy by spleeninvigorating, kidney-tonifying and blood-activating method combined with western medicine
Objective: This article uses a meta-analysis system to evaluate the clinical efficacy of the method of spleen-invigorating, kidney-tonifying and blood-activating combined with western medicine in the treatment of diabetic nephropathy, in order to provide evidence-based medicine for the clinical t...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2021-04-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/202107/09.pdf |
Summary: | Objective: This article uses a meta-analysis system to evaluate the clinical efficacy of the
method of spleen-invigorating, kidney-tonifying and blood-activating combined with western
medicine in the treatment of diabetic nephropathy, in order to provide evidence-based medicine
for the clinical treatment of this disease. Methods: Computer search (January 2009 to June
2020) published in CNKI, Wanfang database, and Weipu Chinese Science and Technology
Journal Database with simple western medicine conventional treatment (control group) and
on the basis of control group Randomized Controlled Trial (RCT) of the treatment of diabetic
nephropathy with spleen-invigorating, kidney-tonifying and blood-activating (experimental
group), and manual retrieval of relevant literature that meets the inclusion criteria. Two
researchers independently carried out literature screening, and used the improved Jadad rating
scale for quality evaluation, and finally used RevMan5.3 statistical software for meta-analysis.
Results: A total of 15 randomized controlled trials were included, with a total of 1218 patients,
including 621 in the experimental group and 597 in the control group. Meta-analysis showed
that the experimental group was improving clinical efficacy (OR=4.35, 95% CI [3.12, 6.08], P
<0.00001), FPG (MD=-0.49, 95% CI [-0.89, -0.09], P=0.02 ), 24h urine protein quantification
(MD=-0.54, 95% CI [-0.90, -0.18], P=0.003), mALB (MD=-15.95, 95% CI [-18.12, -13.79],
P<0.0001) , BUN (MD=-1.79, 95% CI [-2.99, -0.59], P=0.004), SCr (MD=-47.63, 95% CI
[-83.43, -11.83], P=0.009), TC (MD =-1.02, 95% CI [-1.42, -0.62], P<0.00001), etc. may
be better than the control group; The test group is improving TG (MD=-1.02, 95% CI [-1.42,
-0.62], P <0.00001) there is no significant difference compared with the control group.
Conclusion: The method of spleen-invigorating, kidney-tonifying and blood-activating
combined with conventional western medicine treatment of diabetic nephropathy may be
superior to conventional western medicine treatment in terms of improving clinical efficacy,
FPG, 24h urine protein quantification, mALB, BUN, SCr, TC, etc. However, due to the small
number and low quality of the literature included in this study, more in-depth research needs to
further expand the sample size and include higher quality RCTs. |
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ISSN: | 1007-1237 1007-1237 |