PD-L1 siRNA Theranostics With a Dextran Nanoparticle Highlights the Importance of Nanoparticle Delivery for Effective Tumor PD-L1 Downregulation

PD-L1 siRNA Theranostics With a Dextran Nanoparticle Highlights the Importance of Nanoparticle Delivery for Effective Tumor PD-L1 Downregulation

PurposeThe inhibition of immune checkpoints such as programmed cell death ligand-1 (PD-L1/CD274) with antibodies is providing novel opportunities to expose cancer cells to the immune system. Antibody based checkpoint blockade can, however, result in serious autoimmune complications because normal ti...

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Bibliographic Details
Main Authors: Jesus Pacheco-Torres, Marie-France Penet, Balaji Krishnamachary, Yelena Mironchik, Zhihang Chen, Zaver M. Bhujwalla
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
siRNA
PD-L1
theranostics
imaging
biodegradable dextran
PD-L1 downregulation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.614365/full

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