Next generation quantitative genetics in plants
The analysis of continuous phenotypic traits through quantitative trait loci analysis, or QTL analysis, allows identification of the loci responsible for the variation observed in nature. QTL analyses involve establishing associations between genetic markers and the phenotypic variation of a quantit...
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doaj-860653f8727c4a87b872cd3049459c432020-11-24T22:38:07ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2011-11-01210.3389/fpls.2011.0007711424Next generation quantitative genetics in plantsJosé M Jiménez-Gómez0Max Planck Institute for Plant BreedingThe analysis of continuous phenotypic traits through quantitative trait loci analysis, or QTL analysis, allows identification of the loci responsible for the variation observed in nature. QTL analyses involve establishing associations between genetic markers and the phenotypic variation of a quantitative trait in a segregating population. The laborious task of acquiring genetic markers and phenotypes in segregating populations have continuously benefit from technical advances. The new high-throughput sequencing technologies, or HTS, are radically transforming the way QTL analyses are performed. These technologies have the ability of rapidly and inexpensively sequence billions of bases without previous knowledge of the genomes analyzed. The development of HTS has been accompanied by a rapid progress in experimental protocols, computational pipelines and statistical frameworks to fit researchers needs. Some of these advances allow detection of molecular markers and phenotypes with a resolution never achieved before. In this review I discuss the application of HTS in quantitative genetics, focusing on molecular marker discovery, population genotyping and expression profiling for eQTL analysis.http://journal.frontiersin.org/Journal/10.3389/fpls.2011.00077/fullGenomicsRNA-Seqnext generation sequencingPlant geneticsQTL analysiseQTL analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José M Jiménez-Gómez |
spellingShingle |
José M Jiménez-Gómez Next generation quantitative genetics in plants Frontiers in Plant Science Genomics RNA-Seq next generation sequencing Plant genetics QTL analysis eQTL analysis |
author_facet |
José M Jiménez-Gómez |
author_sort |
José M Jiménez-Gómez |
title |
Next generation quantitative genetics in plants |
title_short |
Next generation quantitative genetics in plants |
title_full |
Next generation quantitative genetics in plants |
title_fullStr |
Next generation quantitative genetics in plants |
title_full_unstemmed |
Next generation quantitative genetics in plants |
title_sort |
next generation quantitative genetics in plants |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Plant Science |
issn |
1664-462X |
publishDate |
2011-11-01 |
description |
The analysis of continuous phenotypic traits through quantitative trait loci analysis, or QTL analysis, allows identification of the loci responsible for the variation observed in nature. QTL analyses involve establishing associations between genetic markers and the phenotypic variation of a quantitative trait in a segregating population. The laborious task of acquiring genetic markers and phenotypes in segregating populations have continuously benefit from technical advances. The new high-throughput sequencing technologies, or HTS, are radically transforming the way QTL analyses are performed. These technologies have the ability of rapidly and inexpensively sequence billions of bases without previous knowledge of the genomes analyzed. The development of HTS has been accompanied by a rapid progress in experimental protocols, computational pipelines and statistical frameworks to fit researchers needs. Some of these advances allow detection of molecular markers and phenotypes with a resolution never achieved before. In this review I discuss the application of HTS in quantitative genetics, focusing on molecular marker discovery, population genotyping and expression profiling for eQTL analysis. |
topic |
Genomics RNA-Seq next generation sequencing Plant genetics QTL analysis eQTL analysis |
url |
http://journal.frontiersin.org/Journal/10.3389/fpls.2011.00077/full |
work_keys_str_mv |
AT josemjimenezgomez nextgenerationquantitativegeneticsinplants |
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